The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

Described herein are MK2 inhibitors of Formula (II) and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of autoimmune disorders, chronic inflammatory disorders, acute inflammatory disorders, auto-inflammatory disorders, fibrotic disorders, metabolic disorders, neoplastic disorders, and cardiovascular or cerebrovascular disorders. ##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

##STR00001##

The disclosure features methods of analyzing a fluid extracted from a reservoir, the methods including introducing a first composition featuring a first complexing agent into a reservoir at a first location, extracting a fluid from the reservoir at a second location different from the first location, combining the fluid with a second composition featuring a concentration of a lanthanide ion to form a third composition featuring a concentration of a complex formed by the first complexing agent and the lanthanide ion, exposing a quantity of the complex to electromagnetic radiation for a first time period ending at a time to, detecting fluorescence emission from the quantity of the complex for a second time period starting at a time t.sub.1>t.sub.0, where t.sub.1−t.sub.0 is greater than 2 microseconds, and determining information about a fluid flow path between the first location and the second location.

The disclosure features methods of analyzing a fluid extracted from a reservoir, the methods including introducing a first composition featuring a first complexing agent into a reservoir at a first location, extracting a fluid from the reservoir at a second location different from the first location, combining the fluid with a second composition featuring a concentration of a lanthanide ion to form a third composition featuring a concentration of a complex formed by the first complexing agent and the lanthanide ion, exposing a quantity of the complex to electromagnetic radiation for a first time period ending at a time to, detecting fluorescence emission from the quantity of the complex for a second time period starting at a time t.sub.1>t.sub.0, where t.sub.1−t.sub.0 is greater than 2 microseconds, and determining information about a fluid flow path between the first location and the second location.

A compound represented by formula (I) or formula (II):

##STR00001##

wherein, A represents an oxygen atom or a sulfur atom; X.sup.1 represents a halogeno group, a substituted or unsubstituted C.sub.1-6 alkyl group and so on; m represents the number of X.sup.1 and is any integer of 0 to 5; any two of X.sup.1 may be bound together to form a bivalent hydrocarbon group; Y represents a single bond or a substituted or unsubstituted C.sub.2-6 alkenylene group; Q.sup.1 represents a substituted or unsubstituted C.sub.6-10 arylene group or a substituted or unsubstituted 6- to 10-membered heteroarylene group; Q.sup.2 represents a substituted or unsubstituted C.sub.6-10 aryl group or a substituted or unsubstituted 5- to 6-membered heteroaryl group; Z.sup.q− represents a counter ion; and q represents a valence of the counter ion and is 1 or 2.

A compound represented by formula (I) or formula (II):

##STR00001##

wherein, A represents an oxygen atom or a sulfur atom; X.sup.1 represents a halogeno group, a substituted or unsubstituted C.sub.1-6 alkyl group and so on; m represents the number of X.sup.1 and is any integer of 0 to 5; any two of X.sup.1 may be bound together to form a bivalent hydrocarbon group; Y represents a single bond or a substituted or unsubstituted C.sub.2-6 alkenylene group; Q.sup.1 represents a substituted or unsubstituted C.sub.6-10 arylene group or a substituted or unsubstituted 6- to 10-membered heteroarylene group; Q.sup.2 represents a substituted or unsubstituted C.sub.6-10 aryl group or a substituted or unsubstituted 5- to 6-membered heteroaryl group; Z.sup.q− represents a counter ion; and q represents a valence of the counter ion and is 1 or 2.

Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria Fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.

Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria Fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.