Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.

Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.

The invention relates to an organic molecule having precisely two units of formula I linked to one another via a single bond or a bridge Y

##STR00001##

where
Y=a divalent group;
X=at each occurrence identically or differently CN and CF.sub.3;
D=chemical unit having a structure of the formula I-1:

##STR00002##

where
#=attachment point of the unit of formula I-1 to the structure of formula I;
A and B=independently of one another selected from the group consisting of CRR.sup.1, CR, NR, N, there being a single or double bond between A and B and a single or double bond between B and Z;
Z=a direct bond or a divalent organic bridge which is a substituted or unsubstituted C1-C9-alkylene, C2-C8-alkenylene, C2-C8-alkynylene or arylene group or a combination thereof, CRR.sup.1, CCRR.sup.1, CNR, NR, O, SiRR.sup.1, S, S(O), S(O).sub.2, O-interrupted substituted or unsubstituted C1-C9-alkylene, C2-C8-alkenylene, C2-C8-alkynylene or arylene group, phenyl units or substituted phenyl units.

The present invention relates to methods and compositions for detecting an interaction between a protein and a ligand, comprising: (i) binding at least one fluorescent molecular rotor to said ligand or protein; and (ii) detecting a change in fluorescence emitted by said fluorescent molecular rotor after contact of the bound fluorescent molecular rotor with the other of said ligand or protein, thereby detecting an interaction between the ligand and the protein, wherein the fluorescent molecular rotor comprises: a rotating ?-bond; an electron-donating moiety; an electron-accepting moiety; and a ?-conjugated linker.

The present invention relates to methods and compositions for detecting an interaction between a protein and a ligand, comprising: (i) binding at least one fluorescent molecular rotor to said ligand or protein; and (ii) detecting a change in fluorescence emitted by said fluorescent molecular rotor after contact of the bound fluorescent molecular rotor with the other of said ligand or protein, thereby detecting an interaction between the ligand and the protein, wherein the fluorescent molecular rotor comprises: a rotating ?-bond; an electron-donating moiety; an electron-accepting moiety; and a ?-conjugated linker.

The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.

The present invention also relates to an organic electronic material with the structure of formula (I). It is a kind of hole transport and injection material with good thermal stability, high hole mobility and excellent solubility. The OLEDs prepared thereof have the advantages such as good light emitting efficiency, excellent color purity and long lifetime. ##STR00001##

The present invention also relates to an organic electronic material with the structure of formula (I). It is a kind of hole transport and injection material with good thermal stability, high hole mobility and excellent solubility. The OLEDs prepared thereof have the advantages such as good light emitting efficiency, excellent color purity and long lifetime. ##STR00001##

The invention relates to a compound, to a rubber mixture containing the compound, to a vehicle tire comprising the rubber mixture in at least one component, to a process for preparing the compound and to the use of the compound as aging stabilizer and/or antioxidant and/or dye.

The compound of the invention has the following formula I): I)

##STR00001## where R1 is selected from the group consisting of benzyl and linear, branched and cyclic aliphatic C3 to C12 radicals; and where the R4 and R5 radicals are independently the same or different and are each selected from the group consisting of linear, branched and cyclic aliphatic C1 to C12 radicals, and aryl radicals, cyano radicals, halogen radicals, preferably fluorine, bromine and chlorine, ester radicals, ketone radicals, ether radicals and thioether radicals, where the linear, branched and cyclic aliphatic C1 to C12 radicals and aryl radicals may bear substituents.