Patent classifications
C07D221/04
Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
The present invention provides a compound of the Formula (I): wherein X, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are as defined herein, or a pharmaceutically acceptable salt thereof. ##STR00001##
Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
The present invention provides a compound of the Formula (I): wherein X, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are as defined herein, or a pharmaceutically acceptable salt thereof. ##STR00001##
Process for the preparation of cycloheptapyridine CGRP receptor antagonists
The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process. ##STR00001##
Process for the preparation of cycloheptapyridine CGRP receptor antagonists
The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process. ##STR00001##
Organic light emitting element
Provided is an organic light emitting element having stable performance in the air. The organic light emitting element includes: an anode; a cathode; and a first organic compound layer placed between the anode and the cathode, in which: the organic light emitting element further includes a first organic compound layer placed between the cathode and the emission layer, and a second organic compound layer placed between the emission layer and the first organic compound layer, and brought into contact with the first organic compound layer; the first organic compound layer contains a first organic compound; the second organic compound layer contains a second organic compound; and the first organic compound includes an organic compound represented by the following general formula [1], and the second organic compound includes an organic compound different from the first organic compound ##STR00001##
Organic light emitting element
Provided is an organic light emitting element having stable performance in the air. The organic light emitting element includes: an anode; a cathode; and a first organic compound layer placed between the anode and the cathode, in which: the organic light emitting element further includes a first organic compound layer placed between the cathode and the emission layer, and a second organic compound layer placed between the emission layer and the first organic compound layer, and brought into contact with the first organic compound layer; the first organic compound layer contains a first organic compound; the second organic compound layer contains a second organic compound; and the first organic compound includes an organic compound represented by the following general formula [1], and the second organic compound includes an organic compound different from the first organic compound ##STR00001##
Condensed-cyclic compound and organic light-emitting device including the same
A condensed-cyclic compound of Formula 1: ##STR00001##
wherein, in Formula 1, groups X.sub.1, X.sub.11 to X.sub.14, L.sub.21, L.sub.22, R.sub.21, and R.sub.21, and variables a21, a22, b21, b22, c21, and c22 are described in the specification.
Condensed-cyclic compound and organic light-emitting device including the same
A condensed-cyclic compound of Formula 1: ##STR00001##
wherein, in Formula 1, groups X.sub.1, X.sub.11 to X.sub.14, L.sub.21, L.sub.22, R.sub.21, and R.sub.21, and variables a21, a22, b21, b22, c21, and c22 are described in the specification.
METHYL (R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-4,5,6,7-TETRAHYDRO-1H-CYCLOPENTA[B]PYRIDINE-3-CARBOXYLATE AND METHYL (R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-1,4,5,7-TETRAHYDROFURO[3,4-B]PYRIDINE-3-CARBOXYLATE AS CAV1.2 ACTIVATORS
The present disclosure provides for a compound according to formula (I)
##STR00001##
or a pharmaceutically acceptable salt thereof as Ca.sub.V1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.
METHYL (R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-4,5,6,7-TETRAHYDRO-1H-CYCLOPENTA[B]PYRIDINE-3-CARBOXYLATE AND METHYL (R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-1,4,5,7-TETRAHYDROFURO[3,4-B]PYRIDINE-3-CARBOXYLATE AS CAV1.2 ACTIVATORS
The present disclosure provides for a compound according to formula (I)
##STR00001##
or a pharmaceutically acceptable salt thereof as Ca.sub.V1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.