Patent classifications
C07D231/10
Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.
Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases. ##STR00001##
Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases. ##STR00001##
UBE2K modulators and methods for their use
Provided are compounds of Formula (I): ##STR00001##
and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.
Prodrugs of ALOX-15 inhibitors and methods of using the same
Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.
Prodrugs of ALOX-15 inhibitors and methods of using the same
Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.
AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF
Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin compound of the present invention is a novel ALK5 inhibitor and is for use in treating and/or preventing various ALK5-mediated diseases.
##STR00001##
PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME
Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.
UBE2K MODULATORS AND METHODS FOR THEIR USE
Provided are compounds of Formula (I):
##STR00001##
and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.
Aqueous electrolytes with bis(fluorosulfonyl)imide salt electrolyte and ionic liquid system and batteries using the electrolyte system
An aqueous electrolyte composition suitable for a lithium secondary battery is provided. The aqueous electrolyte composition contains water; lithium bis(fluorosulfonyl) imide (LiFSI); and an ionic liquid comprising an organic cation and a bis(fluorosulfonyl) imide anion (FSI); wherein the ionic liquid is a liquid at 20 C. A lithium secondary battery containing the aqueous electrolyte and a vehicle at least partially powered by the battery are also provided.