The invention relates to heterocyclic sulfonamide derivatives and their use in the treatment and prophylaxis of autoimmune, inflammatory, cardiovascular, neuronal, auditory, renal and metabolic mediated diseases, and to compositions containing said derivatives and processes for their preparation.

The invention relates to heterocyclic sulfonamide derivatives and their use in the treatment and prophylaxis of autoimmune, inflammatory, cardiovascular, neuronal, auditory, renal and metabolic mediated diseases, and to compositions containing said derivatives and processes for their preparation.

There are described compounds of formula (I): (I) and their use as a medicament in the treatment of diseases associated with the abnormal or elevated catabolism of tryptophan, such as, cancer, immunosuppression, viral infection, depression, a neurodegenerative disorder, trauma, age-related cataracts, organ transplant rejection, or an autoimmune disorder in a patient.

##STR00001##

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001## Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001## Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001## Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001## Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001##
Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and
X is an anion; the method comprises cyclization of a halogenated acrylate with Hnig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001##
Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and
X is an anion; the method comprises cyclization of a halogenated acrylate with Hnig's base in a solvent.

Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: ##STR00001##
Wherein R.sup.1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R.sup.2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R.sup.3 and R.sup.4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hnig's base in a solvent.