The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup.− co-transporter or GABA.sub.A receptor.

The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na.sup.+K.sup.+Cl.sup.− co-transporter or GABA.sub.A receptor.

This application provides a lithium-ion battery and an apparatus. The lithium-ion battery includes an electrode assembly and an electrolyte. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. A positive active material of the positive electrode plate includes Li.sub.x1Co.sub.y1M.sub.1-y1O.sub.2-z1Q.sub.z1, where 0.5≤x1≤1.2, 0.8≤y1<1.0, 0≤z1≤0.1, M is selected from one or more of Al, Ti, Zr, Y, and Mg, and Q is selected from one or more of F, Cl, and S. The electrolyte contains an additive A that is a polynitrile six-membered nitrogen-heterocyclic compound with a relatively low oxidation potential. The lithium-ion battery has superb cycle performance and storage performance, especially under high-temperature and high-voltage conditions.

This application provides a lithium-ion battery and an apparatus. The lithium-ion battery includes an electrode assembly and an electrolyte. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. A positive active material of the positive electrode plate includes Li.sub.x1Co.sub.y1M.sub.1-y1O.sub.2-z1Q.sub.z1, where 0.5≤x1≤1.2, 0.8≤y1<1.0, 0≤z1≤0.1, M is selected from one or more of Al, Ti, Zr, Y, and Mg, and Q is selected from one or more of F, Cl, and S. The electrolyte contains an additive A that is a polynitrile six-membered nitrogen-heterocyclic compound with a relatively low oxidation potential. The lithium-ion battery has superb cycle performance and storage performance, especially under high-temperature and high-voltage conditions.

This application provides a lithium-ion battery and an apparatus. The lithium-ion battery includes an electrode assembly and an electrolyte. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. A positive active material of the positive electrode plate includes Li.sub.x1Co.sub.y1M.sub.1-y1O.sub.2-z1Q.sub.z1, where 0.5≤x1≤1.2, 0.8≤y1<1.0, 0≤z1≤0.1, M is selected from one or more of Al, Ti, Zr, Y, and Mg, and Q is selected from one or more of F, Cl, and S. The electrolyte contains an additive A, an additive B, and an additive C. The additive A is a polynitrile six-membered nitrogen-heterocyclic compound with a relatively low oxidation potential. The additive B is a silyl phosphite compound or a silyl phosphate compound or a mixture thereof. The additive C is a halogen substituted cyclic carbonate compound.

This application provides a lithium-ion battery and an apparatus. The lithium-ion battery includes an electrode assembly and an electrolyte. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. A positive active material of the positive electrode plate includes Li.sub.x1Co.sub.y1M.sub.1-y1O.sub.2-z1Q.sub.z1, where 0.5≤x1≤1.2, 0.8≤y1<1.0, 0≤z1≤0.1, M is selected from one or more of Al, Ti, Zr, Y, and Mg, and Q is selected from one or more of F, Cl, and S. The electrolyte contains an additive A, an additive B, and an additive C. The additive A is a polynitrile six-membered nitrogen-heterocyclic compound with a relatively low oxidation potential. The additive B is a silyl phosphite compound or a silyl phosphate compound or a mixture thereof. The additive C is a halogen substituted cyclic carbonate compound.

Compositions may include a corrosion inhibitor including a heterocyclic diamine prepared from the reaction of an alkyl diamine and an aldehyde, wherein the alkyl diamine has the general formula: R4NH(CH.sub.2).sub.nNHR5, where n is an integer between 3 and 6, and R4 and R5 are independently hydrogen or a C2-C30 saturated or unsaturated hydrocarbon radical. Methods may include contacting a metal surface with a corrosion inhibitor composition, wherein the corrosion inhibitor includes a heterocyclic diamine corrosion inhibitor from the reaction of an alkyl diamine and an aldehyde, wherein the alkyl diamine has the general formula: R4NH(CH.sub.2).sub.nNHR5, where n is an integer between 3 and 6, and R4 and R5 are independently hydrogen or a C2-C30 saturated or unsaturated hydrocarbon radical.

Compositions may include a corrosion inhibitor including a heterocyclic diamine prepared from the reaction of an alkyl diamine and an aldehyde, wherein the alkyl diamine has the general formula: R4NH(CH.sub.2).sub.nNHR5, where n is an integer between 3 and 6, and R4 and R5 are independently hydrogen or a C2-C30 saturated or unsaturated hydrocarbon radical. Methods may include contacting a metal surface with a corrosion inhibitor composition, wherein the corrosion inhibitor includes a heterocyclic diamine corrosion inhibitor from the reaction of an alkyl diamine and an aldehyde, wherein the alkyl diamine has the general formula: R4NH(CH.sub.2).sub.nNHR5, where n is an integer between 3 and 6, and R4 and R5 are independently hydrogen or a C2-C30 saturated or unsaturated hydrocarbon radical.

Use of a transforming growth factor beta (TGF-β) signalling inhibitor for producing a population of brown adipocytes in vitro.

The present application provides a lithium-ion battery and an apparatus, the lithium-ion battery includes an electrode assembly and an electrolyte, the electrode assembly includes a positive electrode sheet, a negative electrode sheet and a separator. A positive active material of the positive electrode sheet includes both Li.sub.x1Co.sub.y1M1.sub.1-y1O.sub.2-aQ1.sub.a and Li.sub.lNi.sub.m1Co.sub.n1M2.sub.pM3.sub.qO.sub.2-bQ2.sub.b, a mass ratio of Li.sub.x1Co.sub.y1M1.sub.1-y1O.sub.2-aQ1.sub.a and Li.sub.lNi.sub.m1Co.sub.n1M2.sub.pM3.sub.qO.sub.2-bQ2.sub.b is 1:1-9:1. The electrolyte contains an additive A, the additive A is a six-membered nitrogen heterocyclic compound with multiple nitrile groups and with low oxidation potential. The lithium-ion battery according to the present application has excellent cycle performance and storage performance, especially under high temperature and high voltage conditions.