Patent classifications
C07D241/10
Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
The invention provides a compound of Formula I, ##STR00001##
Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.
Compounds useful as inhibitors of ATR kinase
- Jean-Damien Charrier ,
- Hayley Marie Binch ,
- Dennis James HURLEY ,
- Thomas Cleveland ,
- Pramod Joshi ,
- Lev Tyler Dewey Fanning ,
- Joanne Pinder ,
- Michael O'Donnell ,
- Anisa Nizarali Virani ,
- Ronald Marcellus Alphonsus Knegtel ,
- Steven John Durrant ,
- Stephen Clinton Young ,
- Pierre-Henri Storck ,
- David Kay ,
- Philip Michael Reaper ,
- Matthew Paul Grote
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: ##STR00001##
wherein the variables are as defined herein.
Preparation of substituted diaminopyrazine dicarboxylic acids
The present invention provides improved methods for preparing a compound comprising Formula (I).
FORMATION OF N-PROTECTED 3,6-BIS-(4-AMINOBUTYL)-2,5-DIKETOPIPERAZINE THROUGH A CYCLIC ALPHA-N-PROTECTED AMINO ESTER INTERMEDIATE
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic -N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
FORMATION OF N-PROTECTED 3,6-BIS-(4-AMINOBUTYL)-2,5-DIKETOPIPERAZINE THROUGH A CYCLIC ALPHA-N-PROTECTED AMINO ESTER INTERMEDIATE
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic -N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.