Provided are compounds of Formula (I):

##STR00001##

or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R.sup.1, R.sup.2, R.sup.3, G.sub.1, G.sub.2, and G.sub.3 are as defined herein.

Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired.

The present invention provides an agrohorticultural fungicide and a method of use thereof of, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof:

##STR00001##

{wherein X.sup.1, X.sup.2, X.sup.3 and X.sup.4 denote a hydrogen atom or the like, A, B, Y, denote a single bond or carbonyl group or the like, Q denotes a (C.sub.1-C.sub.6)alkyl group or hetero ring or the like, R.sup.5 and R.sup.6 denote a hydrogen atom or (C.sub.1-C.sub.6)alkyl group or the like.}.

In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired.

The present invention provides an agrohorticultural fungicide and a method of use thereof of, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof:

##STR00001##

{wherein X.sup.1, X.sup.2, X.sup.3 and X.sup.4 denote a hydrogen atom or the like, A, B, Y, denote a single bond or carbonyl group or the like, Q denotes a (C.sub.1-C.sub.6)alkyl group or hetero ring or the like, R.sup.5 and R.sup.6 denote a hydrogen atom or (C.sub.1-C.sub.6)alkyl group or the like.}.

The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-L1, and/or PD-L2.

Substituted aromatic sulfonamides of formula (I)

##STR00001##

pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Substituted aromatic sulfonamides of formula (I)

##STR00001##

pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.

##STR00001##

The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.

##STR00001##

The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.

The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.