Patent classifications
C07D275/03
FARNESOID X RECEPTOR AGONISTS AND USES THEREOF
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
USE OF ISOTIANIL FOR CONTROL OF ZEBRA CHIP DISEASE
The present invention relates to the novel use of an isothiazolecarboxamide of the formula (I)
##STR00001##
(common name: Isotianil)
for controlling Candidatus Liberibacter spp and/or Candidatus Phytoplasma spp, preferably, Candidatus Liberibacter solanacearum and/or Candidatus Phytoplasma americanum, more preferred Candidatus Liberibacter solanacearum, in plants of the Solanaceae family, preferably in potatoes.
USE OF ISOTIANIL FOR CONTROL OF ZEBRA CHIP DISEASE
The present invention relates to the novel use of an isothiazolecarboxamide of the formula (I)
##STR00001##
(common name: Isotianil)
for controlling Candidatus Liberibacter spp and/or Candidatus Phytoplasma spp, preferably, Candidatus Liberibacter solanacearum and/or Candidatus Phytoplasma americanum, more preferred Candidatus Liberibacter solanacearum, in plants of the Solanaceae family, preferably in potatoes.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Sulfonylaminobenzamide compounds as anthelmintics
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates. ##STR00001##
Sulfonylaminobenzamide compounds as anthelmintics
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates. ##STR00001##
1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.
1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.
SULFOMALEIMIDE-BASED LINKERS AND CORRESPONDING CONJUGATES
The present invention relates to a linker of the following formula (I) or a salt thereof:
##STR00001##
The present invention relates to a linker-drug conjugate of the following formula (II) or a salt thereof:
##STR00002##
The present invention relates also to a binding unit-drug conjugate, such as an antibody-drug conjugate, of the following formula (III) or (IV) or a salt thereof:
##STR00003##
as well as a pharmaceutical composition comprising such a binding unit-drug conjugate and its use in the treatment of cancer.