The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

##STR00001##

The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

##STR00001##

The present invention relates to compounds of Formula (I), ##STR00001##
or a form thereof, wherein ring A, R.sub.1, R.sub.2, R.sub.3, R.sub.3, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

The present invention relates to compounds of Formula (I), ##STR00001##
or a form thereof, wherein ring A, R.sub.1, R.sub.2, R.sub.3, R.sub.3, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

The invention provides compounds of formula I: ##STR00001##
or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.

This invention provides a polymerizable compound represented by formula (I), a polymerizable composition containing the polymerizable compound and a polymerization initiator, a polymer produced by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic product comprising the polymer as a constituent material. In formula (1), Y.sup.1 to Y.sup.9 represent O, S, OC(O), C(O)O or the like, G.sup.1 and G.sup.2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z.sup.1 to Z.sup.3 represent an alkenyl group having 2 to 10 carbon atoms or the like, A.sup.x represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A.sup.1 represents a trivalent aromatic group or the like, A.sup.2 and A.sup.3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A.sup.4 and A.sup.5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q.sup.1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1. ##STR00001##

This invention provides a polymerizable compound represented by formula (I), a polymerizable composition containing the polymerizable compound and a polymerization initiator, a polymer produced by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic product comprising the polymer as a constituent material. In formula (1), Y.sup.1 to Y.sup.9 represent O, S, OC(O), C(O)O or the like, G.sup.1 and G.sup.2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z.sup.1 to Z.sup.3 represent an alkenyl group having 2 to 10 carbon atoms or the like, A.sup.x represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A.sup.1 represents a trivalent aromatic group or the like, A.sup.2 and A.sup.3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A.sup.4 and A.sup.5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q.sup.1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1. ##STR00001##

The present invention is directed to novel chemical compositions of matter, and in particular a novel MDMA class of compounds MDMA analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a MDMA basic or modified side chain.

The present invention is directed to novel chemical compositions of matter, and in particular a novel MDMA class of compounds MDMA analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a MDMA basic or modified side chain.

The present invention relates to the following compounds for use in the treatment of a bacterial infection

##STR00001##

wherein the integers are as defined in the description. The invention also relates to compounds for use as medicaments, pharmaceutical compositions and some novel compounds.