Patent classifications
C07D277/62
SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME
The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME
The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF
A compound containing a benzene ring as shown in formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, an isotopic compound thereof, a crystal form thereof, a nitrogen oxide thereof, and a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof are provided. The compound has high P2X4 antagonistic activity, good selectivity, low toxicity and good metabolic stability.
##STR00001##
Pnictogen-containing heterocyclic compounds and their use
Disclosed are pnictogen-containing heterocyclic compounds of Formula (I) ##STR00001##
Each of R.sub.1, the heterocyclic ring H, A.sup.+, LG, and X.sup. is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.
Pnictogen-containing heterocyclic compounds and their use
Disclosed are pnictogen-containing heterocyclic compounds of Formula (I) ##STR00001##
Each of R.sub.1, the heterocyclic ring H, A.sup.+, LG, and X.sup. is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.
3-substituted phenylamidine compounds, preparation and use thereof
The present invention disclosed 3-substituted phenylamidine compounds of general formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, A and E have the same meanings as defined in description. The present invention further discloses methods for their preparation and use of the compounds of general formula (I) as a crop protection agent. ##STR00001##
Short-acting 3,4-methylenedioxymethamphetamine (MDMA) analogs incorporating benzothiazole
The present invention is directed to chemical compositions of matter, and in particular a MDMA class of analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a basic or modified side chain.
Short-acting 3,4-methylenedioxymethamphetamine (MDMA) analogs incorporating benzothiazole
The present invention is directed to chemical compositions of matter, and in particular a MDMA class of analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a basic or modified side chain.