The invention relates to small, conjugatable, orthogonal and tunable fluorophores for imaging of small bioactive molecules. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications. The invention provides a compound of formula (I), a derivative or a salt thereof. Wherein X is selected from the group consisting of NH, O, S, SeR5R6, CR7R8; R1 is selected from the group consisting of amines, alcohols, thiols, thiophenols, selenols, selenophenols and aryl groups; R2 and R3 are independently H or a halogen; R4 tis either H, nitro or cyano; R5 is either absent or methyl or oxygen; R6 is either absent or methyl or oxygen; and R7 and R8 are independently selected from the group consisting of linear or cyclic alkyl groups containing halogen, amino, cyano or carboxylic ester substituents, and alkyl aryl groups.

##STR00001##

The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitre and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

##STR00001##

The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitre and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

##STR00001##

An organic compound represented by [1], satisfying (i) and (ii), and represented by [2-1] or [2-2].

A-(B).sub.m  [1] (i) T.sub.1 of the unit A<T.sub.1 of the unit B, and (ii) HOMO-LUMO orbitals responsible for T.sub.1 transition are present in the unit A,

##STR00001## wherein R.sub.1 is selected from alkyl groups and the like, m denotes an integer of 1 or more and 5 or less, and n denotes an integer of 0 or more and 4 or less, the unit B is a fused ring with a partial structure represented by the general formula [3-1] or [3-2] or the like and is bonded to the unit A via a carbon atom, wherein X is selected from an oxygen atom, a sulfur atom, and the like, and the rings C to E independently denote a single ring and may have a deuterium atom or an alkyl group.

An organic compound represented by [1], satisfying (i) and (ii), and represented by [2-1] or [2-2].

A-(B).sub.m  [1] (i) T.sub.1 of the unit A<T.sub.1 of the unit B, and (ii) HOMO-LUMO orbitals responsible for T.sub.1 transition are present in the unit A,

##STR00001## wherein R.sub.1 is selected from alkyl groups and the like, m denotes an integer of 1 or more and 5 or less, and n denotes an integer of 0 or more and 4 or less, the unit B is a fused ring with a partial structure represented by the general formula [3-1] or [3-2] or the like and is bonded to the unit A via a carbon atom, wherein X is selected from an oxygen atom, a sulfur atom, and the like, and the rings C to E independently denote a single ring and may have a deuterium atom or an alkyl group.

The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitro and cyano: and R5 and R6 independently are either absent or oxygen or methyl. ##STR00001##

The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitro and cyano: and R5 and R6 independently are either absent or oxygen or methyl. ##STR00001##

The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.

##STR00001##

The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.

##STR00001##

The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans. ##STR00001##