A method for producing propylene oxide involves an oxidation step, a distillation step, an epoxidation step, and a separation step. The distillation step involves distilling the reaction mixture containing cumene hydroperoxide to separate it into a concentrate containing cumene hydroperoxide and a distillate. The reaction mixture is continuously distilled so that the ratio of the flow rate of the distillate to the flow rate of the reaction mixture to be distilled is 0.037 to 0.13. The epoxidation step involves obtaining a reaction mixture containing propylene oxide and cumyl alcohol by contacting the concentrate with propylene in the presence of a catalyst in one or more reactors to cause a reaction between propylene and cumene hydroperoxide in the concentrate, in which the outlet temperature of the final reactor is adjusted to 115 C. or more and less than 140 C.

A method for producing propylene oxide involves an oxidation step, a distillation step, an epoxidation step, and a separation step. The distillation step involves distilling the reaction mixture containing cumene hydroperoxide to separate it into a concentrate containing cumene hydroperoxide and a distillate. The reaction mixture is continuously distilled so that the ratio of the flow rate of the distillate to the flow rate of the reaction mixture to be distilled is 0.037 to 0.13. The epoxidation step involves obtaining a reaction mixture containing propylene oxide and cumyl alcohol by contacting the concentrate with propylene in the presence of a catalyst in one or more reactors to cause a reaction between propylene and cumene hydroperoxide in the concentrate, in which the outlet temperature of the final reactor is adjusted to 115 C. or more and less than 140 C.

Methods for the preparation of the following compound are disclosed.

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The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

Methods for the preparation of the following compound are disclosed.

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The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

This invention relates to a process for the epoxidation of a tetrasubstituted alkene such as terpinolene to the corresponding epoxide such as terpinolene epoxide by reacting the tetrasubstituted alkene with performic acid prepared in situ from formic acid and hydrogen peroxide in the presence of at least one buffering agent. Further, the invention relates to the use of an oxidizing agent comprising hydrogen peroxide and formic acid for the in-situ epoxidation of a tetrasubstituted alkene.

This invention relates to a process for the epoxidation of a tetrasubstituted alkene such as terpinolene to the corresponding epoxide such as terpinolene epoxide by reacting the tetrasubstituted alkene with performic acid prepared in situ from formic acid and hydrogen peroxide in the presence of at least one buffering agent. Further, the invention relates to the use of an oxidizing agent comprising hydrogen peroxide and formic acid for the in-situ epoxidation of a tetrasubstituted alkene.

A system for recovering a sterilization agent may include a pressure reducing value for reducing a pressure of a waste gas from a sterilization chamber to a first predefined pressure. The waste gas may include a gaseous mixture of a sterilization agent, nitrogen gas, and water vapor. A first condenser may cool the gaseous mixture to below a boiling point temperature and above a freezing point temperature of the water vapor at the first predefined pressure. A first tank may store the condensed water vapor. A separation pump may raise the pressure of the gaseous mixture to a second predefined pressure. A second condenser may cool the gaseous mixture to below a boiling point temperature and above a freezing point temperature of the sterilization agent at the second predefined pressure causing the sterilization agent to condense into a liquid. A second tank may store the separated sterilization agent.

A system for recovering a sterilization agent may include a pressure reducing value for reducing a pressure of a waste gas from a sterilization chamber to a first predefined pressure. The waste gas may include a gaseous mixture of a sterilization agent, nitrogen gas, and water vapor. A first condenser may cool the gaseous mixture to below a boiling point temperature and above a freezing point temperature of the water vapor at the first predefined pressure. A first tank may store the condensed water vapor. A separation pump may raise the pressure of the gaseous mixture to a second predefined pressure. A second condenser may cool the gaseous mixture to below a boiling point temperature and above a freezing point temperature of the sterilization agent at the second predefined pressure causing the sterilization agent to condense into a liquid. A second tank may store the separated sterilization agent.

A method of using biopolymer to synthesize titanium-containing silicon oxide material and applications thereof are disclosed. The method comprises steps: mixing a titanium source, a silicon source, an acid source, a base source, a biopolymer and a solvent to form an aqueous solution, and letting the aqueous solution react to form a semi-product; performing aging, solid-liquid separation and drying of the semi-product to obtain a dried solid; and performing calcination or extraction of the dried solid to obtain a titanium-containing silicon oxide material with a high specific surface area. The present invention adopts a biopolymer as the templating agent, which makes the fabrication process of titanium-containing silicon oxide material more environment-friendly. After calcination or extraction, the product still has superior catalytic activity, able to catalyze epoxidation of olefins and favorable for the production of epoxide.

A method of using biopolymer to synthesize titanium-containing silicon oxide material and applications thereof are disclosed. The method comprises steps: mixing a titanium source, a silicon source, an acid source, a base source, a biopolymer and a solvent to form an aqueous solution, and letting the aqueous solution react to form a semi-product; performing aging, solid-liquid separation and drying of the semi-product to obtain a dried solid; and performing calcination or extraction of the dried solid to obtain a titanium-containing silicon oxide material with a high specific surface area. The present invention adopts a biopolymer as the templating agent, which makes the fabrication process of titanium-containing silicon oxide material more environment-friendly. After calcination or extraction, the product still has superior catalytic activity, able to catalyze epoxidation of olefins and favorable for the production of epoxide.