Disclosed is a propylene direct oxidation reaction catalyst capable of preparing a propylene oxide from propylene and oxygen at a higher yield than catalysts prepared by conventional methods, by applying a specific transition metal oxide promoter in preparation of a catalyst containing silver, a transition metal oxide promoter and a carrier through a slurry process. The present invention provides a propylene direct oxidation reaction catalyst, which is a supported silver catalyst used for preparing a propylene oxide from the propylene direct oxidation reaction, the catalyst including a molybdenum oxide and a tungsten oxide as a catalyst promoter.

The present invention is related to a process for preparing propylene oxide, comprising (i) providing a stream comprising propene, hydrogen peroxide or a source of hydrogen peroxide, water, and an organic solvent; (ii) passing the liquid feed stream provided in (i) into an epoxidation zone comprising an epoxidation catalyst comprising a titanium zeolite, and subjecting the liquid feed stream to epoxidation reaction conditions in the epoxidation zone, obtaining a reaction mixture comprising propene, propylene oxide, water, and the organic solvent; (iii) removing an effluent stream from the epoxidation zone, the effluent stream comprising propylene oxide, water, organic solvent, and propene; (iv) separating propene from the effluent stream by distillation, comprising (iv.1) subjecting the effluent stream to distillation conditions in a distillation unit, obtaining a gaseous top stream S0 enriched in propene compared to the effluent stream subjected to distillation conditions, and a liquid bottoms stream S01 enriched in propylene oxide, water and organic solvent compared to the effluent stream subjected to distillation conditions; (iv.2) returning a condensed portion of the stream S0 to an upper part of the distillation unit.

The present disclosure relates to a method for effecting catalytic selective oxidation in liquid phase comprising a perfluorinated solvent and an olefinic compound with molecular oxygen to produce an epoxide. The method may provide enhanced selectivity to the epoxide of greater than 60%. The olefinic compound may be ethylene, propylene, butenes, 1-octene, butadiene, allyl chloride, allyl alcohol, styrene, and the like. The perfluorinated solvent may be perfluoro methyldecalin, perfluorodecalin, perfluoroperhydrophenanthrene, perfluoro (butyltetrahydrofuran), isomers thereof, or a combination thereof. In some embodiments, the method includes catalytically epoxidizing, in a liquid phase comprising a perfluorinated solvent, propylene with molecular oxygen to produce propylene oxide. A system for carrying out the method is also provided, the system comprising a source of a perfluorinated solvent, and a liquid phase reactor fluidly connected with the source, and configured for effecting catalytic selective oxidation, in a liquid phase comprising the perfluorinated solvent, of an olefinic compound with molecular oxygen to produce an epoxide.

The present disclosure relates to a method for effecting catalytic selective oxidation in liquid phase comprising a perfluorinated solvent and an olefinic compound with molecular oxygen to produce an epoxide. The method may provide enhanced selectivity to the epoxide of greater than 60%. The olefinic compound may be ethylene, propylene, butenes, 1-octene, butadiene, allyl chloride, allyl alcohol, styrene, and the like. The perfluorinated solvent may be perfluoro methyldecalin, perfluorodecalin, perfluoroperhydrophenanthrene, perfluoro (butyltetrahydrofuran), isomers thereof, or a combination thereof. In some embodiments, the method includes catalytically epoxidizing, in a liquid phase comprising a perfluorinated solvent, propylene with molecular oxygen to produce propylene oxide. A system for carrying out the method is also provided, the system comprising a source of a perfluorinated solvent, and a liquid phase reactor fluidly connected with the source, and configured for effecting catalytic selective oxidation, in a liquid phase comprising the perfluorinated solvent, of an olefinic compound with molecular oxygen to produce an epoxide.

The present invention relates to a process for preparing terpinene-4-ol from limonene-4-ol via a hydrogenation reaction in the presence of a nickel catalyst.

The composition of the present invention related to a quaternary ammonium salt detergent and the use of such quaternary ammonium salt detergents in a fuel composition to reduce diesel injector deposits and remove or clean up existing deposits on the diesel injectors.

The composition of the present invention related to a quaternary ammonium salt detergent and the use of such quaternary ammonium salt detergents in a fuel composition to reduce diesel injector deposits and remove or clean up existing deposits on the diesel injectors.

During start-up of a continuous epoxidation of propene with hydrogen peroxide in a methanol solvent with a shaped titanium silicalite catalyst in a tube bundle reactor with a cooling jacket, cooling medium is fed at the rate for full load of the reactor with a constant entry temperature of from 20 C. to 50 C., methanol solvent is fed at a rate of from 50 to 100% for full load of the reactor, hydrogen peroxide is fed at a rate that starts with no more than 10% of the rate for full load and is increased continuously or stepwise to maintain a maximum temperature in the fixed bed of no more than 60 C. and a difference between the maximum temperature in the fixed bed and the cooling medium entry temperature of no more than 20 C., and propene is fed at a rate of from 20 to 100% of the rate for full load, increasing the feeding rate when the molar ratio of propene to hydrogen peroxide reaches the molar ratio for full load.

During start-up of a continuous epoxidation of propene with hydrogen peroxide in a methanol solvent with a shaped titanium silicalite catalyst in a tube bundle reactor with a cooling jacket, cooling medium is fed at the rate for full load of the reactor with a constant entry temperature of from 20 C. to 50 C., methanol solvent is fed at a rate of from 50 to 100% for full load of the reactor, hydrogen peroxide is fed at a rate that starts with no more than 10% of the rate for full load and is increased continuously or stepwise to maintain a maximum temperature in the fixed bed of no more than 60 C. and a difference between the maximum temperature in the fixed bed and the cooling medium entry temperature of no more than 20 C., and propene is fed at a rate of from 20 to 100% of the rate for full load, increasing the feeding rate when the molar ratio of propene to hydrogen peroxide reaches the molar ratio for full load.

Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.