Patent classifications
C07D303/36
K-RAS MODULATORS
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.
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NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF
The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF
The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
Nebivolol synthesis method and intermediate compound thereof
The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
Nebivolol synthesis method and intermediate compound thereof
The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
Process for preparation of an aromatic N-glycidylamine
A process for preparing an aromatic N-glycidylamine comprising a step of heating a mixture of an amine having at least one aromatic aminohydrogen atom with at least 0.7 equivalent of epichlorohydrin per aminohydrogen equivalent of the amine in presence of a catalyst dissolved in an inert organic solvent, at a pressure in a range of 200 mbar to 600 mbar; and adding a base to the mixture at a pressure in a range of 200 mbar to 600 mbar to facilitate dehydrochlorination of product of the previous step to obtain the aromatic N-glycidylamine.
Process for preparation of an aromatic N-glycidylamine
A process for preparing an aromatic N-glycidylamine comprising a step of heating a mixture of an amine having at least one aromatic aminohydrogen atom with at least 0.7 equivalent of epichlorohydrin per aminohydrogen equivalent of the amine in presence of a catalyst dissolved in an inert organic solvent, at a pressure in a range of 200 mbar to 600 mbar; and adding a base to the mixture at a pressure in a range of 200 mbar to 600 mbar to facilitate dehydrochlorination of product of the previous step to obtain the aromatic N-glycidylamine.
PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.
PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.
Process for preparing aminotetrahydropyrans
The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).