Patent classifications
C07D303/48
2,3-butanediamide epoxide compound and preparation method and use thereof
Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses. ##STR00001##
Substituted aminobutyric derivatives as neprilysin inhibitors
The present invention provides a compound of formula I; ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Substituted aminobutyric derivatives as neprilysin inhibitors
The present invention provides a compound of formula I; ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
NOVEL CYSTEINE PROTEASE INHIBITORS AND USES THEREOF
The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.
NOVEL CYSTEINE PROTEASE INHIBITORS AND USES THEREOF
The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.
Method for producing compound
A method by which an intermediate product of an azole derivative can be produced at a lower cost than known production methods is provided. A method for producing a compound represented by General Formula (IV) includes converting a compound represented by General Formula (II) into the compound represented by General Formula (IV) using (a) dimethyl sulfide and/or dimethyl sulfoxide, and (b) a methyl-LG (an LG is a nucleophilically substitutable leaving group and is selected from the group consisting of a halogen group, an alkoxysulfonyloxy group, an aryloxysulfonyloxy group, an alkylsulfonyloxy group, a haloalkylsulfonyloxy group, and an arylsulfonyloxy group) in the presence of an inorganic base.
Method for producing compound
A method by which an intermediate product of an azole derivative can be produced at a lower cost than known production methods is provided. A method for producing a compound represented by General Formula (IV) includes converting a compound represented by General Formula (II) into the compound represented by General Formula (IV) using (a) dimethyl sulfide and/or dimethyl sulfoxide, and (b) a methyl-LG (an LG is a nucleophilically substitutable leaving group and is selected from the group consisting of a halogen group, an alkoxysulfonyloxy group, an aryloxysulfonyloxy group, an alkylsulfonyloxy group, a haloalkylsulfonyloxy group, and an arylsulfonyloxy group) in the presence of an inorganic base.
Compounds and Their Use in Filtering Ultraviolet and/or High-Energy Visible Light
This invention provides compounds of formula (II) or tautomers, stereoisomers, hydrates, solvates, salts, or polymorphs thereof.
##STR00001##
wherein Z.sup.1a, X.sup.1a, Ar.sup.1, X.sup.2a, W.sup.1a, Y.sup.1a, R.sup.1a, R.sup.2a, R.sup.3a, and R.sup.4a have the same meaning as that defined in the description and claims. The invention also provides these compounds for use in filtering ultraviolet (UV) and high-energy visible light. The invention also relates to compositions comprising said compounds. The present invention also relates to consumer products and packaging material comprising said compounds.
Compounds and Their Use in Filtering Ultraviolet and/or High-Energy Visible Light
This invention provides compounds of formula (II) or tautomers, stereoisomers, hydrates, solvates, salts, or polymorphs thereof.
##STR00001##
wherein Z.sup.1a, X.sup.1a, Ar.sup.1, X.sup.2a, W.sup.1a, Y.sup.1a, R.sup.1a, R.sup.2a, R.sup.3a, and R.sup.4a have the same meaning as that defined in the description and claims. The invention also provides these compounds for use in filtering ultraviolet (UV) and high-energy visible light. The invention also relates to compositions comprising said compounds. The present invention also relates to consumer products and packaging material comprising said compounds.