The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof:

##STR00001##

wherein X is an oxygen atom and the like; Y is CO, SO.sub.2 and the like; R.sup.1 is an optionally-substituted C.sub.1-6 alkyl group, an optionally-substituted C.sub.1-6 alkylcarbonyl group and the like; R.sup.2 is an optionally-substituted C.sub.1-6 alkyl group, an optionally-substituted C.sub.1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof:

##STR00001##

wherein X is an oxygen atom and the like; Y is CO, SO.sub.2 and the like; R.sup.1 is an optionally-substituted C.sub.1-6 alkyl group, an optionally-substituted C.sub.1-6 alkylcarbonyl group and the like; R.sup.2 is an optionally-substituted C.sub.1-6 alkyl group, an optionally-substituted C.sub.1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

A monomer, an organic layer composition, an organic layer, and a method of forming a pattern, the monomer being represented by the following Chemical Formula 1: ##STR00001##

A monomer, an organic layer composition, an organic layer, and a method of forming a pattern, the monomer being represented by the following Chemical Formula 1: ##STR00001##

The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.

The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.

The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

An organic electroluminescent element includes a light emitting layer including, as host materials, an anthracene-based compound represented by the following general formula (1) and a dibenzochrysene-based compound represented by the following general formula (2), and further including a dopant material.

##STR00001## (X and Ar.sup.4 in formula (1) each represent a hydrogen atom, an optionally substituted aryl, or the like, and R.sup.1 to R.sup.16 in formula (2) each represent a hydrogen atom, an aryl, or the like.)