Patent classifications
C07D309/28
RXFP1 AGONISTS
- Shun Su ,
- Donna M. Bilder ,
- Adam James Clarke ,
- Heather Finlay ,
- Todd J. Friends ,
- Arvind Mathur ,
- Michael C. Myers ,
- R. Michael Lawrence ,
- Jianqing Li ,
- Donald J.P. PINTO ,
- Michael J. Orwat ,
- Kumar Balashanmuga Pabbisetty ,
- Scott A. Shaw ,
- Leon M. Smith, II ,
- George O. Tora ,
- Benjamin P. Vokits ,
- Daniel O'Malley ,
- Nicholas R. Wurtz ,
- Vikram Bhogadi ,
- Laxman Pasunoori ,
- Pitani Veera Venkata Srinivas ,
- Sreekantha Ratna Kumar ,
- Hima Kiran Potturi ,
- Subramanya Hegde
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).
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RXFP1 AGONISTS
- Shun Su ,
- Donna M. Bilder ,
- Adam James Clarke ,
- Heather Finlay ,
- Todd J. Friends ,
- Arvind Mathur ,
- Michael C. Myers ,
- R. Michael Lawrence ,
- Jianqing Li ,
- Donald J.P. PINTO ,
- Michael J. Orwat ,
- Kumar Balashanmuga Pabbisetty ,
- Scott A. Shaw ,
- Leon M. Smith, II ,
- George O. Tora ,
- Benjamin P. Vokits ,
- Daniel O'Malley ,
- Nicholas R. Wurtz ,
- Vikram Bhogadi ,
- Laxman Pasunoori ,
- Pitani Veera Venkata Srinivas ,
- Sreekantha Ratna Kumar ,
- Hima Kiran Potturi ,
- Subramanya Hegde
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).
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Compositions and methods for the treatment of viral infections
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
Compositions and methods for the treatment of viral infections
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).