Provided herein, inter alia, are compounds and methods for treating infectious diseases. The compounds provided herein are, inter alia, useful for the treatment of bacterial infections. The compounds provided herein are, inter alia, useful inhibitors of metalloproteins, e.g. UDP-3-O(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC).

Provided herein, inter alia, are compounds and methods for treating infectious diseases. The compounds provided herein are, inter alia, useful for the treatment of bacterial infections. The compounds provided herein are, inter alia, useful inhibitors of metalloproteins, e.g. UDP-3-O(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC).

The invention provides compounds of formula Ia, Ib and Ic: ##STR00001##
and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

The invention provides compounds of formula Ia, Ib and Ic: ##STR00001##
and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations comprising compounds of the formula (I).

The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations comprising compounds of the formula (I).

This invention provides for use of a compound of formula (1) for inhibiting a post-germination ethylene production response in a plant or plant part and a method of inhibiting a post-germination ethylene production response of a plant or plant part comprising delivering a compound of formula (1) to a plant or plant part.

##STR00001##

This invention provides for use of a compound of formula (1) for inhibiting a post-germination ethylene production response in a plant or plant part and a method of inhibiting a post-germination ethylene production response of a plant or plant part comprising delivering a compound of formula (1) to a plant or plant part.

##STR00001##

The present disclosure relates to the technical field of drug synthesis, and particularly relates to a Hispidin derivative, and a preparation method and use thereof. The Hispidin derivative has a structure of formula (I):

##STR00001##

The present disclosure employs 4-hydroxy-6-methyl-2-pyrone and 3,4-dihydroxybenzaldehyde as starting raw materials to synthesize a series of compounds with styrylpyrone as a backbone. The preparation method provided by the present disclosure has simple steps, is easy to operate, has good feasibility, has the potential for large-scale industrial application, and has a broad market prospect. The present disclosure further provides use of the preparation method described above and the resulting Hispidin derivative in preparation of a lipid-lowering drug. The aryl compound provided by the present disclosure has a good lipid-lowering therapeutic effect and can be used for preparing a lipid-lowering drug, thus having good social benefits.

The present disclosure relates to the technical field of drug synthesis, and particularly relates to a Hispidin derivative, and a preparation method and use thereof. The Hispidin derivative has a structure of formula (I):

##STR00001##

The present disclosure employs 4-hydroxy-6-methyl-2-pyrone and 3,4-dihydroxybenzaldehyde as starting raw materials to synthesize a series of compounds with styrylpyrone as a backbone. The preparation method provided by the present disclosure has simple steps, is easy to operate, has good feasibility, has the potential for large-scale industrial application, and has a broad market prospect. The present disclosure further provides use of the preparation method described above and the resulting Hispidin derivative in preparation of a lipid-lowering drug. The aryl compound provided by the present disclosure has a good lipid-lowering therapeutic effect and can be used for preparing a lipid-lowering drug, thus having good social benefits.