Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

##STR00001##

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

##STR00001##

The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

The present invention relates to compounds of general formula (I) ##STR00001## wherein R.sup.1-R.sup.8 take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly for the treatment and/or prophylaxis of cancer.

The present invention relates to compounds of general formula (I) ##STR00001## wherein R.sup.1-R.sup.8 take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly for the treatment and/or prophylaxis of cancer.

The invention relates to a compound of Formula (I), wherein n is 0 or 1, R.sub.1 is H or CH.sub.3 and R.sub.2 is a linear (C.sub.3-C.sub.6)alkyl and an insecticide composition comprising at least one insecticide active ingredient and at least one a compound of Formula (I).

The invention relates to a compound of Formula (I), wherein n is 0 or 1, R.sub.1 is H or CH.sub.3 and R.sub.2 is a linear (C.sub.3-C.sub.6)alkyl and an insecticide composition comprising at least one insecticide active ingredient and at least one a compound of Formula (I).

The present invention relates to a browning-inhibiting composition containing a compound represented by the following formula (1):

##STR00001##

wherein R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.26 and R.sup.27 each independently represent a hydrogen atom or a substituent, and at least one of R.sup.21 or R.sup.23 is a hydrogen atom; when R.sup.23 represents a hydrogen atom, at least one of R.sup.22 or R.sup.24 represents a substituent; R.sup.25 represents a hydrogen atom, an oxygen atom, or a substituent; R.sup.22 and R.sup.23, or R.sup.23 and R.sup.24 may be bonded together to form a ring with an oxygen atom and a carbon atom to which these Rs are bonded; R.sup.25 and R.sup.26, or R.sup.26 and R.sup.27 may be bonded together to form a ring structure with carbon atoms to which these Rs are bonded; X represents an oxygen atom or CH.sub.2; and a dashed line may represent a double bond.

The present invention relates to a browning-inhibiting composition containing a compound represented by the following formula (1):

##STR00001##

wherein R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.26 and R.sup.27 each independently represent a hydrogen atom or a substituent, and at least one of R.sup.21 or R.sup.23 is a hydrogen atom; when R.sup.23 represents a hydrogen atom, at least one of R.sup.22 or R.sup.24 represents a substituent; R.sup.25 represents a hydrogen atom, an oxygen atom, or a substituent; R.sup.22 and R.sup.23, or R.sup.23 and R.sup.24 may be bonded together to form a ring with an oxygen atom and a carbon atom to which these Rs are bonded; R.sup.25 and R.sup.26, or R.sup.26 and R.sup.27 may be bonded together to form a ring structure with carbon atoms to which these Rs are bonded; X represents an oxygen atom or CH.sub.2; and a dashed line may represent a double bond.