C07D311/04

A SMALL MOLECULE COMPOUND AND ITS USE AND PREPARATION METHOD
20240391892 · 2024-11-28 ·

The present invention relates to a small molecular compound and its application as an active ingredient in cosmetics, as well as its preparation method. The small molecular compound is represented by the following chemical formula:

##STR00001##

Wherein, R1 is selected from compounds represented by the following formula:

##STR00002##

C1 represents a five-or six-membered carbon ring or heterocycle, while R11 stands for alkyl or ester groups with multiple substitutions on the ring.

##STR00003##

C2 represents an aromatic ring, while R12 stands for alkyl, ester, carbonyl, ether groups, or cyclic substituents formed by bridging two adjacent substituents on the ring with multiple substitutions.

##STR00004##

R13, R13, R13, identical or different, are selected from hydrogen, ester groups, alkyl, alkenyl, and cycloalkenyl. R2 is chosen from

##STR00005##

This compound exhibits antioxidant properties when used as a reagent.

A SMALL MOLECULE COMPOUND AND ITS USE AND PREPARATION METHOD
20240391892 · 2024-11-28 ·

The present invention relates to a small molecular compound and its application as an active ingredient in cosmetics, as well as its preparation method. The small molecular compound is represented by the following chemical formula:

##STR00001##

Wherein, R1 is selected from compounds represented by the following formula:

##STR00002##

C1 represents a five-or six-membered carbon ring or heterocycle, while R11 stands for alkyl or ester groups with multiple substitutions on the ring.

##STR00003##

C2 represents an aromatic ring, while R12 stands for alkyl, ester, carbonyl, ether groups, or cyclic substituents formed by bridging two adjacent substituents on the ring with multiple substitutions.

##STR00004##

R13, R13, R13, identical or different, are selected from hydrogen, ester groups, alkyl, alkenyl, and cycloalkenyl. R2 is chosen from

##STR00005##

This compound exhibits antioxidant properties when used as a reagent.

Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops.

The present invention relates to compositions and methods for controlling infections in plant crops, comprising the application of metabolites to crops infected with various microorganisms, such as microorganisms of the genus Pseudomonas, Erwinia, Bacillus, Botrytis and Phytophthora. The invention also relates to the use of a compound selected from: 2,4-dihydroxy-3-(methyl-2-buten-1-yl) dihydrochalcone (1); glabranine (2), isochordine (3), 2,4-dihydroxychalcone (4), 7-Hydroxyflavanone (5), chordine (6), izalpinine (7), 2,4-dihydroxydihydrochalcone (8), 2,4-dimethoxydihydrochalcone (9) and 2,4,6-trihydroxy chalcone (10), in order to prepare an agrochemical composition to control infections in plant crops.

THERAPEUTIC COMPOUNDS

The invention provides compounds formula (I) and salts thereof: wherein the bond represented by ---- is a single bond or a double bond, and R1 has any of the values defined in the specification. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

##STR00001##

THERAPEUTIC COMPOUNDS

The invention provides compounds formula (I) and salts thereof: wherein the bond represented by ---- is a single bond or a double bond, and R1 has any of the values defined in the specification. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

##STR00001##

Anhydrous crystalline form of S-equol
09914718 · 2018-03-13 · ·

An anhydrous crystalline form of S-equol has been discovered. Form I, the anhydrous crystalline form of S-equol has been isolated and characterized for the first time. As compared to other forms of S-equol, such as the known hydrate or other solvate forms, the anhydrous crystalline form of S-equol has improved properties.

Anhydrous crystalline form of S-equol
09914718 · 2018-03-13 · ·

An anhydrous crystalline form of S-equol has been discovered. Form I, the anhydrous crystalline form of S-equol has been isolated and characterized for the first time. As compared to other forms of S-equol, such as the known hydrate or other solvate forms, the anhydrous crystalline form of S-equol has improved properties.

Inhibitors of histone deacetylase

The present invention relates to compounds of formula (I): ##STR00001##
or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

Inhibitors of histone deacetylase

The present invention relates to compounds of formula (I): ##STR00001##
or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS

The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.

##STR00001##