The present invention relates to substituted hexahydro-5H-chromen-5-one and/or substituted tetrahydrobenzofuran-4(2H)-one derivatives which are useful as fragrance or flavor materials.

The present invention relates to substituted hexahydro-5H-chromen-5-one and/or substituted tetrahydrobenzofuran-4(2H)-one derivatives which are useful as fragrance or flavor materials.

The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.

A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.

The present invention relates to a compound which can be used in the treatment of infections caused by SARS coronaviruses, e.g. by blocking the active site of the proteases 3CL.sup.pro and PL.sup.pro. The compound can be used as inhibitor or label as such or can be used in screening methods for profiling other inhibitors. Moreover, the present invention relates to a method of producing the compound.

The present invention relates to a compound which can be used in the treatment of infections caused by SARS coronaviruses, e.g. by blocking the active site of the proteases 3CL.sup.pro and PL.sup.pro. The compound can be used as inhibitor or label as such or can be used in screening methods for profiling other inhibitors. Moreover, the present invention relates to a method of producing the compound.

The invention relates to compounds of formula (I) and related aspects.

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