The invention relates to a novel process for preparing spiroketal-substituted cyclic ketoenols which can be used as insecticides, acaricides or herbicides. The present invention also relates to novel intermediates for the preparation of spiroketal-substituted cyclic ketoenols.

The invention relates to a novel process for preparing spiroketal-substituted cyclic ketoenols which can be used as insecticides, acaricides or herbicides. The present invention also relates to novel intermediates for the preparation of spiroketal-substituted cyclic ketoenols.

The invention relates to a distillative process for the preparation of a diastereomer-enriched odorant mixture, and to the diastereomer-enriched odorant mixture and its use as an odorant or for the preparation of an odorant composition. Furthermore, the invention relates to the use of the diastereomer-enriched odorant mixture for imparting, modifying or enhancing a floral odour note of a perfumed product or for the preparation of a perfumed product. Finally, the present invention also relates to odorant compositions and perfumed products comprising the diastereomer-enriched odorant composition.

The invention relates to a distillative process for the preparation of a diastereomer-enriched odorant mixture, and to the diastereomer-enriched odorant mixture and its use as an odorant or for the preparation of an odorant composition. Furthermore, the invention relates to the use of the diastereomer-enriched odorant mixture for imparting, modifying or enhancing a floral odour note of a perfumed product or for the preparation of a perfumed product. Finally, the present invention also relates to odorant compositions and perfumed products comprising the diastereomer-enriched odorant composition.

The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis.

The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis.

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

The present invention relates to intermediate compounds for the synthesis of novel cannabinoids 1 and 2, synthesized from simple starting materials using a cascade sequence of allylic rearrangement, aromatization and, for tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2 are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ.sup.8-tetrahydrocannabinol. The analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis oil.

##STR00001##

Novel compounds of the formulas 3 and 6, useful as intermediates for the synthesis of the cannabinoids of advanced intermediates 4 and 5 as well as cannabinoids of the formulas 1 and 2, are disclosed.

##STR00002##

The present invention relates to intermediate compounds for the synthesis of novel cannabinoids 1 and 2, synthesized from simple starting materials using a cascade sequence of allylic rearrangement, aromatization and, for tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2 are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ.sup.8-tetrahydrocannabinol. The analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis oil.

##STR00001##

Novel compounds of the formulas 3 and 6, useful as intermediates for the synthesis of the cannabinoids of advanced intermediates 4 and 5 as well as cannabinoids of the formulas 1 and 2, are disclosed.

##STR00002##

Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.