Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.

Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.

Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.

Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.

A compound represented by the formula (I):

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.a, X.sup.b, L.sup.1, L.sup.2, L.sup.3 and L.sup.4 are defined in the specification.

A compound represented by the formula (I):

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.a, X.sup.b, L.sup.1, L.sup.2, L.sup.3 and L.sup.4 are defined in the specification.

Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof. ##STR00001##