A process for preparing the benzothiophen-2-yl boronate of formula (VI) which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of proliferative disorders, such as cancer and tumor diseases.

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A process for preparing the benzothiophen-2-yl boronate of formula (VI) which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of proliferative disorders, such as cancer and tumor diseases.

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Provided herein are compositions comprising a compound of Formulas I, II, or III, and compositions a compound comprising a moiety of Formula IV, which are useful for sensitizing and/or activating pro-apoptotic activity of BAX. Methods of treating diseases associated with BAX (e.g., cancer) and methods of identifying compounds which sensitize and/or activate the pro-apoptotic activity of a BAX polypeptide are also provided.

Provided herein are compositions comprising a compound of Formulas I, II, or III, and compositions a compound comprising a moiety of Formula IV, which are useful for sensitizing and/or activating pro-apoptotic activity of BAX. Methods of treating diseases associated with BAX (e.g., cancer) and methods of identifying compounds which sensitize and/or activate the pro-apoptotic activity of a BAX polypeptide are also provided.

In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging organism Normal tissue and/or age-related diseases.

In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging organism Normal tissue and/or age-related diseases.

To provide an organic compound represented by the following general formula (1): ##STR00001##
where R.sub.1 is a C2-C6 alkyl group or a hydrogen atom, R.sub.2 and R.sub.3, which may be identical or different, are each a C2-C12 alkyl group, and R.sub.4 and R.sub.5, which may be identical or different, are each a C6-C12 alkyl group that may be a branched chain or a straight chain.

The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions.

Compounds having activity as inhibitors of Gl2C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein B, Z, R.sup.a, R.sup.b, R.sup.c, R.sup.1, L, L.sup.1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of Gl2C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

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The present specification relates to a heterocyclic compound represented by Chemical Formula 1 and an organic light emitting device including the same.