C07D333/74

SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS

Disclosed are compounds of Formula (I), Formula (II), Formula (III), and Formula (IV) or salts thereof, wherein R.sub.2 is OH or OP(O)(OH).sub.2; and R.sub.1 is defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

##STR00001##

Organic electroluminescent element and electronic device

The compound represented by formula (1): ##STR00001##
wherein A, B, R.sup.1, and R.sup.2 are as defined in the description,
provides organic electroluminescence (EL) devices having a high emission efficiency when operated at low voltage and a long lifetime and electronic devices including such organic EL devices.

Organic electroluminescent element and electronic device

The compound represented by formula (1): ##STR00001##
wherein A, B, R.sup.1, and R.sup.2 are as defined in the description,
provides organic electroluminescence (EL) devices having a high emission efficiency when operated at low voltage and a long lifetime and electronic devices including such organic EL devices.

ORGANIC ELECTROLUMINESCENT DEVICE

The present disclosure relates to organic electroluminescent devices. The organic electroluminescent device according to the present disclosure exhibits improved lifespan characteristics and progressive driving voltage by including at least one deuterated compound(s).

NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT
20190135773 · 2019-05-09 ·

The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.

NOVEL COMPOSITIONS AND METHODS FOR CANCER TREATMENT
20190135773 · 2019-05-09 ·

The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.

NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
20190100654 · 2019-04-04 ·

This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE

The compound represented by formula (1):

##STR00001##

wherein A, B, R.sup.1, and R.sup.2 are as defined in the description, provides organic electroluminescence (EL) devices having a high emission efficiency when operated at low voltage and a long lifetime and electronic devices including such organic EL devices.

DINAPHTHOTHIOPHENE COMPOUNDS

The present invention generally relates to various dinaphthothiophene compounds and processes for preparing these compounds.

SYNTHETIC METHOD OF FUSED HETEROAROMATIC COMPOUND AND FUSED HETEROAROMATIC COMPOUND, AND INTERMEDIATE THEREOF

A method of synthesizing a fused heteroaromatic compound includes obtaining a first intermediate from a first compound represented by Chemical Formula 1 and a second compound represented by Chemical Formula 2, obtaining a second intermediate including a ring having a chalcogen element from the first intermediate, and obtaining a fused heteroaromatic compound by a cyclization reaction of the second intermediate.