An organic compound represented by the following general formula [1] is excellent in thermal stability. ##STR00001##
In the general formula [1], R.sub.1 to R.sub.12 are each independently selected from the group consisting of a hydrogen atom and a substituent. Symbol A is selected from the group consisting of a divalent residue of naphthalene, phenanthrene, fluorene, benzofluorene, dibenzofluorene or spirofluorene, and a heteroarylene group having 4 to 12 carbon atoms. Symbol B is selected from the group consisting of an arylene group having 6 to 25 carbon atoms and a heteroarylene group having 4 to 12 carbon atoms. Symbol n is an integer of 0 to 3.

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.

A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof:

##STR00001##

wherein each symbol is as defined in the SPECIFICATION.

Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer.

A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof:

##STR00001##

wherein each symbol is as defined in the SPECIFICATION.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

A compound represented by the following formula (1) (L.sub.1 is a single bond or an unsubstituted arylene group having 6 to 50 ring carbon atoms, and Ar.sub.1 is a substituted or unsubstituted aryl group having 6 to 50 ring carbon atoms).

##STR00001##

The invention relates to an organic molecule, in particular for use in organic optoelectronic devices. According to the invention, the organic molecule has one first chemical moiety with a structure of formula I, ##STR00001## and one second chemical moiety with a structure of formula II, ##STR00002## wherein the first chemical moiety is linked to the second chemical moiety via a single bond.

The invention relates to an organic molecule, in particular for use in organic optoelectronic devices. According to the invention, the organic molecule has one first chemical moiety with a structure of formula I, ##STR00001## and one second chemical moiety with a structure of formula II, ##STR00002## wherein the first chemical moiety is linked to the second chemical moiety via a single bond.

The present disclosure relates to a plurality of host materials comprising at least one first host compound represented by the following formula 1 and at least one second host compound represented by the following formula 2, and an organic electroluminescent device comprising the same. By comprising the specific combination of the compound according to the present disclosure as host materials, an organic electroluminescent device having high luminous efficiency and/or long lifespan characteristics can be provided.