The present disclosure relates to salts and polymorphs of aminoalkylfumagillol carbamates (e.g., fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate benzenesulfonic acid salt and fumagill-6-yl N-(trans-4-aminocyclohexyl)carbamate hydroxynaphthoic acid salt). The polymorphs are characterized by X-ray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis, among other methods. The polymorphs and salts can be used as intermediates in the production of fumagillol derivatives (e.g., polymer-conjugated fumagillol derivatives) as well as therapeutic agents for the treatment of various diseases and conditions such as cancer.

A solid fuel boiler with one or more fuel chutes configured to pre-dry wet solid fuel prior to loading into a combustion chamber of the boiler, enabling higher thermal efficiencies and burning less fuel to produce the same steam quantity. The pre-drying fuel chutes pass through the boiler where hot combustion gases radiantly and convectivelyheat the chute walls to dry the wet solid fuel by radiant, convective, and/or conductive heating. Agitator mechanisms or structures within the chute mix the fuel for uniform heating, break up clumps of wet fuel, regulate the speed of falling fuel, prevent sticking, dry the fuel by means of steam and/or hot air, transport and deliver a cooling medium while a chute is offline in an operating boiler, and suppress fire using steam injection. Fuel from the chute can flow into a fuel storage bin or directly into the combustion zone of the furnace.

Disclosed are organic compounds including a structure of formula (I-1). Also provided are mixtures containing the organic compounds, and at least one organic functional material. Further provided are organic electronic devices containing a functional layer, the functional layer comprises the organic compounds. The present disclosure can achieve better device performance through device structure optimization, especially to achieve high-performance OLED devices, which provides better material and preparation technology options for full-color display and lighting applications.

Disclosed are organic compounds including a structure of formula (I-1). Also provided are mixtures containing the organic compounds, and at least one organic functional material. Further provided are organic electronic devices containing a functional layer, the functional layer comprises the organic compounds. The present disclosure can achieve better device performance through device structure optimization, especially to achieve high-performance OLED devices, which provides better material and preparation technology options for full-color display and lighting applications.

The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.

The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.

The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

Method for producing carboxylic anhydride, the method includes heating raw material compound represented by the following general formula (1):

##STR00001##

[in the formula (1), R.sup.1 is tetravalent organic group having at least two carbon atoms adjacent to each other, and groups represented by the formulae: COOR.sup.2 and COOR.sup.3 are bonded to one and the other of the two adjacent carbon atoms, respectively, R.sup.2 and R.sup.3 each represent hydrogen atom or the like, X represents hydrogen atom or the like, and Y represents hydrogen atom or the like] in carboxylic acid having 1 to 5 carbon atoms with catalyst being used, to thereby obtain the carboxylic anhydride, wherein the catalyst is homogeneous acid catalyst having acid dissociation constant (pKa) of 6.5 or lower and boiling point of 100 C. or higher, the acid dissociation constant (pKa) being determined by quantum chemistry calculation based on density functional method.