Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

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The present disclosure provides an organic compound of following formula and an organic light emitting diode and an OLED device including the organic compound. ##STR00001##

The present disclosure provides an organic compound of following formula and an organic light emitting diode and an OLED device including the organic compound. ##STR00001##

A compound represented by the formula (12X). In the formula (12X), Py.sub.1 and Py.sub.2 each independently represent a substituted or unsubstituted 1-pyrenyl group, L.sub.1 and L.sub.2 each independently represent a substituted or unsubstituted phenylene group or a substituted or unsubstituted naphthylene group. When L.sub.1 and L.sub.2 each independently represent a substituted or unsubstituted phenylene group, -L.sub.1-L.sub.2- in the formula (12X) represents a group represented by one of the formulae (13-1) to (13-6), (10-1), (20-1), and (30-1). When L.sub.1 and L.sub.2 each independently represent a substituted or unsubstituted naphthylene group, a bonding position of the naphthylene group in L.sub.1 is different from a bonding position of the naphthylene group in L.sub.2.

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The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. Applying the organic compound into an emissive layer makes the OLED and the organic light emitting device lower their driving voltage, improves their luminous efficiency and color purity. ##STR00001##

The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. Applying the organic compound into an emissive layer makes the OLED and the organic light emitting device lower their driving voltage, improves their luminous efficiency and color purity. ##STR00001##

Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.

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Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.

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This invention relates to compounds of formula (I) and their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction. ##STR00001##

An organic electroluminescence device comprising: a cathode, an anode, and an organic layer disposed between the cathode and the anode, wherein the organic layer comprises a compound represented by the following formula (1), and a compound A having a Stokes shift of 20 nm or smaller and an emission peak wavelength of 440 nm to 465 nm (at least one of Ar.sub.1 and Ar.sub.2 is a monovalent group having a structure represented by the following formula (2)).

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