C07D409/10

Carbon monoxide releasing molecules and associated methods

The present disclosure relates to carbon monoxide releasing molecules (“CORMs”), and methods of synthesizing and applying the molecules. More specifically, this disclosure relates to structurally tunable CORMS, compounds containing CORMS (and salts thereof). An exemplary compound includes: ##STR00001##

Carbon monoxide releasing molecules and associated methods

The present disclosure relates to carbon monoxide releasing molecules (“CORMs”), and methods of synthesizing and applying the molecules. More specifically, this disclosure relates to structurally tunable CORMS, compounds containing CORMS (and salts thereof). An exemplary compound includes: ##STR00001##

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

PROCESS FOR THE SYNTHESIS OF N-BUTYLOXYCARBONYL-3-(4-IMIDAZOL-1- YLMETHYLPHENYL)-5-ISO-BUTYLTHIOPHENE-2-SULFONAMIDE
20230183223 · 2023-06-15 ·

There is provided a new process for the synthesis of compounds of formula I, which are useful as angiotensin (Ang II) type 2 receptor agonists: by reacting a compound of formula II, with an excess of a compound of formula III, wherein W, Z and X have meanings given in the description; followed by reaction of the intermediate so formed with a suitable source of the counter-ion, W.

##STR00001##

PROCESS FOR THE SYNTHESIS OF N-BUTYLOXYCARBONYL-3-(4-IMIDAZOL-1- YLMETHYLPHENYL)-5-ISO-BUTYLTHIOPHENE-2-SULFONAMIDE
20230183223 · 2023-06-15 ·

There is provided a new process for the synthesis of compounds of formula I, which are useful as angiotensin (Ang II) type 2 receptor agonists: by reacting a compound of formula II, with an excess of a compound of formula III, wherein W, Z and X have meanings given in the description; followed by reaction of the intermediate so formed with a suitable source of the counter-ion, W.

##STR00001##

NITROGEN-CONTAINING COMPOUND, ELECTRONIC ELEMENT, AND ELECTRONIC DEVICE
20230183191 · 2023-06-15 ·

The present disclosure belongs to the field of organic light-emitting materials, and provides a nitrogen-containing compound, an electronic element and an electronic device. The structure of the nitrogen-containing compound is shown as Formula 1, wherein X.sub.1, X.sub.2 and X.sub.3 are each independently selected from C(H) or N, and at least one of the three is selected from N; and Ar.sub.1 and Ar.sub.2 are each independently selected from a substituted or unsubstituted aryl with 6 to 40 carbon atoms. The nitrogen-containing compound can improve performance of the electronic element.

##STR00001##

NITROGEN-CONTAINING COMPOUND, ELECTRONIC ELEMENT, AND ELECTRONIC DEVICE
20230183191 · 2023-06-15 ·

The present disclosure belongs to the field of organic light-emitting materials, and provides a nitrogen-containing compound, an electronic element and an electronic device. The structure of the nitrogen-containing compound is shown as Formula 1, wherein X.sub.1, X.sub.2 and X.sub.3 are each independently selected from C(H) or N, and at least one of the three is selected from N; and Ar.sub.1 and Ar.sub.2 are each independently selected from a substituted or unsubstituted aryl with 6 to 40 carbon atoms. The nitrogen-containing compound can improve performance of the electronic element.

##STR00001##

ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME

The present invention relates to: an anthracene derivative compound having a specific structure; and an organic light-emitting device having low-voltage driving characteristics, comprising same, and also relates to an organic light-emitting device, which employs, as a dopant compound, a polycyclic aromatic derivative compound having a specific structure together in a light-emitting layer, and thus has excellent light-emitting characteristics such as further improved low-voltage driving.

Condensed-cyclic compound and organic light-emitting device comprising the same

A condensed-cyclic compound represented by Formula 1 and an organic light-emitting device including the condensed-cyclic compound. ##STR00001##
wherein R.sub.1 to R.sub.10 are defined as in the specification.