The present invention relates to a pyrrolo[2,1-f][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1-f][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1-f][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.

The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.

The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.

The present invention discloses a compound of formula (I), ##STR00001##
wherein, R.sup.1, L.sup.1, A, k, L.sup.2, W, L.sup.4, R.sup.5, R.sup.8 and R.sup.9 are as defined in the detailed description. The present invention further discloses a process for preparing the compound of formula (I).

The present invention discloses a compound of formula (I), ##STR00001##
wherein, R.sup.1, L.sup.1, A, k, L.sup.2, W, L.sup.4, R.sup.5, R.sup.8 and R.sup.9 are as defined in the detailed description. The present invention further discloses a process for preparing the compound of formula (I).