Serotonin receptor modulators and methods of making and using the same are disclosed herein.

Serotonin receptor modulators and methods of making and using the same are disclosed herein.

The invention relates to small, conjugatable, orthogonal and tunable fluorophores for imaging of small bioactive molecules. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications. The invention provides a compound of formula (I), a derivative or a salt thereof. Wherein X is selected from the group consisting of NH, O, S, SeR5R6, CR7R8; R1 is selected from the group consisting of amines, alcohols, thiols, thiophenols, selenols, selenophenols and aryl groups; R2 and R3 are independently H or a halogen; R4 tis either H, nitro or cyano; R5 is either absent or methyl or oxygen; R6 is either absent or methyl or oxygen; and R7 and R8 are independently selected from the group consisting of linear or cyclic alkyl groups containing halogen, amino, cyano or carboxylic ester substituents, and alkyl aryl groups. ##STR00001##

The present invention relates to compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions of the compounds, or salts thereof, that can inhibit secreted phospholipases A2 (sPLA2-X) enzymes, wherein the compound is a compound of Formula (I), wherein Ring B, R.sub.6, Z.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 are described herein. The invention also relates to the use of the compounds, salts, or compositions described herein in methods of inhibiting sPLA2-X enzymes in a sample. The invention also relates to the use of the compounds, salts, or compositions in methods of treating or lessening the severity of an sPLA2-X mediated disease in a subject.

##STR00001##

The present invention relates to compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions of the compounds, or salts thereof, that can inhibit secreted phospholipases A2 (sPLA2-X) enzymes, wherein the compound is a compound of Formula (I), wherein Ring B, R.sub.6, Z.sub.1, Z.sub.2, Z.sub.3, and Z.sub.4 are described herein. The invention also relates to the use of the compounds, salts, or compositions described herein in methods of inhibiting sPLA2-X enzymes in a sample. The invention also relates to the use of the compounds, salts, or compositions in methods of treating or lessening the severity of an sPLA2-X mediated disease in a subject.

##STR00001##