C07D471/20

DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY

Provided herein are compounds of formula (I):

##STR00001##

and pharmaceutically acceptable salts thereof, where the substituents are as described herein. These compounds and their pharmaceutical compositions may be useful in the treatment of oncologic diseases.

KRATOM OPIOID DERIVATIVES FOR THE TREATMENT OF ALCOHOL USE DISORDER

In some aspects, the present disclosure provides compounds of the formula:

##STR00001##

wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the consumption of alcohol in a patient. These compounds may be used in treat or prevent alcoholism or an alcohol abuse disorder and show an improved pharmaceutical profile relative to other commonly used compounds.

KRATOM OPIOID DERIVATIVES FOR THE TREATMENT OF ALCOHOL USE DISORDER

In some aspects, the present disclosure provides compounds of the formula:

##STR00001##

wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the consumption of alcohol in a patient. These compounds may be used in treat or prevent alcoholism or an alcohol abuse disorder and show an improved pharmaceutical profile relative to other commonly used compounds.

CONDENSED CYCLIC COMPOUND, ORGANIC LIGHT EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT EMITTING DEVICE

Provided are a condensed cyclic compound represented by Formula 1, an organic light-emitting device including the condensed cyclic compound, and an electronic apparatus including the organic light-emitting device:

##STR00001## wherein, in Formula 1, the substituents may be understood by referring to the detailed description.

CONDENSED CYCLIC COMPOUND, ORGANIC LIGHT EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT EMITTING DEVICE

Provided are a condensed cyclic compound represented by Formula 1, an organic light-emitting device including the condensed cyclic compound, and an electronic apparatus including the organic light-emitting device:

##STR00001## wherein, in Formula 1, the substituents may be understood by referring to the detailed description.

Mitragynine analogs for the treatment of pain, mood disorders and substance use disorders

The present invention provides a compound having the structure: ##STR00001##
or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.

Mitragynine analogs for the treatment of pain, mood disorders and substance use disorders

The present invention provides a compound having the structure: ##STR00001##
or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.

HETEROCYCLIC COMPOUND FOR USE IN ELECTRONIC DEVICES

The present invention relates to heterocyclic compounds, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.

Quinolino-pyrrolidin-2-one derivative and application thereof

Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof. ##STR00001##

Quinolino-pyrrolidin-2-one derivative and application thereof

Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof. ##STR00001##