The present invention provides a method for obtaining a specifically-shaped crystal (specifically, spherocrystal) of a compound with good reproducibility. This method for producing a specifically-shaped crystal (specifically spherocrystal) of a compound comprises: (1) a step for preparing a supersaturated solution of a compound having a degree of supersaturation equal to or higher than a critical degree of supersaturation; and (2) a step for precipitating a specifically-shaped crystal (specifically spherocrystal) of a compound from the supersaturated solution.

The present invention relates to a compound having the following formula (I): (I) wherein: —R is a (C.sub.1-C.sub.6)alkyl group; —R″ is preferably H; —Ar is a (C.sub.5-C.sub.12)arylene radical; —X.sub.1 is —C(═O)—or —SO.sub.2—; and —R′ is chosen from the group consisting of possibly substituted (C.sub.1-C.sub.6)alkyl, heteroaryl, (C.sub.5-C.sub.12)aryl, and (hetero)cycloalkyl groups, or a pharmaceutically acceptable salt and/or tautomeric form thereof, or its racemates, diastereomers or enantiomers. ##STR00001##

The present invention relates to a compound having the following formula (I): (I) wherein: —R is a (C.sub.1-C.sub.6)alkyl group; —R″ is preferably H; —Ar is a (C.sub.5-C.sub.12)arylene radical; —X.sub.1 is —C(═O)—or —SO.sub.2—; and —R′ is chosen from the group consisting of possibly substituted (C.sub.1-C.sub.6)alkyl, heteroaryl, (C.sub.5-C.sub.12)aryl, and (hetero)cycloalkyl groups, or a pharmaceutically acceptable salt and/or tautomeric form thereof, or its racemates, diastereomers or enantiomers. ##STR00001##

This invention relates to xanthine derivative compounds that are inhibitors of BET bromodomains proteins, the method of preparation thereof and applications thereof. ##STR00001##

This invention relates to xanthine derivative compounds that are inhibitors of BET bromodomains proteins, the method of preparation thereof and applications thereof. ##STR00001##

Described herein are cyclic amide-containing pyridyl-xanthines of formula I and pharmaceutical compositions thereof that are useful as antagonists of A2B adenosine receptors. ##STR00001##

Compounds of formula I (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as pesticides and can be prepared in a manner known per se. ##STR00001##

Disclosed are new intermediates for the synthesis of Linagliptin and of its salts and a process for its preparation involving said intermediates.

Disclosed are new intermediates for the synthesis of Linagliptin and of its salts and a process for its preparation involving said intermediates.

The present invention relates to a method for preparing a 2-fluoropurine marked with the radioisotope .sup.18F comprising a fluorination step for a 2-nitropurine derivative. The present invention comprises a 2-fluoropurine derivative marked with the radioisotope .sup.18F which can be obtained by or during a method according to the invention and its various uses.