The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

Provided is an opto-electronic device including a first electrode, a second electrode facing the first electrode, and a photoactive layer arranged between the first electrode and the second electrode, wherein the photoactive layer includes a first layer and a second layer, the first layer including a first compound, and the second layer including a second compound that does not include a 5-membered ring, the first compound is an electron-donating compound, the second compound is an electron-accepting compound, and the opto-electronic device satisfies Equation 1:

0.1?(E.sup.1.sub.LUMO?E.sup.2.sub.LUMO)/(E.sup.1.sub.LUMO?E.sup.1.sub.HOMO)?0.5Equation 1 wherein, in Equation 1, E.sup.1.sub.LUMO, E.sup.1.sub.HOMO, and E.sup.2.sub.LUMO are each as defined herein.

Provided is an opto-electronic device including a first electrode, a second electrode facing the first electrode, and a photoactive layer arranged between the first electrode and the second electrode, wherein the photoactive layer includes a first layer and a second layer, the first layer including a first compound, and the second layer including a second compound that does not include a 5-membered ring, the first compound is an electron-donating compound, the second compound is an electron-accepting compound, and the opto-electronic device satisfies Equation 1:

0.1?(E.sup.1.sub.LUMO?E.sup.2.sub.LUMO)/(E.sup.1.sub.LUMO?E.sup.1.sub.HOMO)?0.5Equation 1 wherein, in Equation 1, E.sup.1.sub.LUMO, E.sup.1.sub.HOMO, and E.sup.2.sub.LUMO are each as defined herein.

Provided are compounds, including compositions comprising the same, which function to recruit various target proteins (e.g., client proteins of 14-3-3 proteins) to an E3 ubiquitin ligase enzyme for ubiquitination and subsequent degradation, and methods of using the same.

Provided are compounds, including compositions comprising the same, which function to recruit various target proteins (e.g., client proteins of 14-3-3 proteins) to an E3 ubiquitin ligase enzyme for ubiquitination and subsequent degradation, and methods of using the same.

The present disclosure relates to organic electroluminescent devices. The organic electroluminescent device according to the present disclosure exhibits improved lifespan characteristics and progressive driving voltage by including at least one deuterated compound(s).

The present disclosure relates to an organic compound of Formula 1, and an organic light emitting diode including the organic compound and an organic light emitting display device including the organic compound. The organic light emitting diode comprises a first electrode, a second electrode facing the first electrode, and a first emitting material layer positioned between the first and second electrodes, where the first emitting material layer includes the organic compound. The organic light emitting display device comprises a substrate, the above organic light emitting diode over the substrate, and an encapsulation film covering the organic light emitting diode.

##STR00001##

The present disclosure relates to an organic compound of Formula 1, and an organic light emitting diode including the organic compound and an organic light emitting display device including the organic compound. The organic light emitting diode comprises a first electrode, a second electrode facing the first electrode, and a first emitting material layer positioned between the first and second electrodes, where the first emitting material layer includes the organic compound. The organic light emitting display device comprises a substrate, the above organic light emitting diode over the substrate, and an encapsulation film covering the organic light emitting diode.

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Methods of making low odor choline salts of an organic compound, for example, choline ellagate compound(s), and uses and formulations thereof.