Certain embodiments are directed to oridonin analogs or derivatives. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents.

The present invention belongs to the field of medicinal technique, specifically relates to nitrogen-containing heterocyclic ring-substituted dihydroartemisinin derivatives and their optical isomers according to formula I or II; wherein substituent X, Y, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the Description. The derivatives and compositions thereof can be prepared into clinically acceptable tablets, capsules, injections, ointments, etc., and thus have pharmaceutical uses in the treatment and/or prevention of cancers. ##STR00001##

The present invention belongs to the field of medicinal technique, specifically relates to nitrogen-containing heterocyclic ring-substituted dihydroartemisinin derivatives and their optical isomers according to formula I or II; wherein substituent X, Y, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the Description. The derivatives and compositions thereof can be prepared into clinically acceptable tablets, capsules, injections, ointments, etc., and thus have pharmaceutical uses in the treatment and/or prevention of cancers. ##STR00001##

The present invention relates to compounds of formula (I), which are artemisinin-derivative N-heterocyclic carbene gold (1) hybrid complexes, and to their therapeutic uses.

The present invention belongs to a process for separating and purifying artemisinin comprising S1. concentrating and pressure filtering an artemisinin extraction liquid to obtain a crude artemisinin crystal 1 and a mother liquor 1, and concentrating the mother liquor 1 to obtain an artemisinin extract 1; S2. adding the artemisinin extract 1 to an aqueous alcohol solution to obtain an aqueous alcohol extraction liquid 1 and an artemisinin extract 2; S3. subjecting the artemisinin extract 2 to S2 so as to obtain an aqueous alcohol extraction liquid 2 and an artemisinin extract 3; S4. combining the aqueous alcohol extraction liquids 1 and 2 to obtain a crude artemisinin crystal 2 and a mother liquor 2; and S5. combining the crude artemisinin crystals 1 and 2, then dissolving same in an alcohol solvent and filtering same, heating the filtrate and then concentrating same to obtain a fine artemisinin product.

The present invention belongs to a process for separating and purifying artemisinin comprising S1. concentrating and pressure filtering an artemisinin extraction liquid to obtain a crude artemisinin crystal 1 and a mother liquor 1, and concentrating the mother liquor 1 to obtain an artemisinin extract 1; S2. adding the artemisinin extract 1 to an aqueous alcohol solution to obtain an aqueous alcohol extraction liquid 1 and an artemisinin extract 2; S3. subjecting the artemisinin extract 2 to S2 so as to obtain an aqueous alcohol extraction liquid 2 and an artemisinin extract 3; S4. combining the aqueous alcohol extraction liquids 1 and 2 to obtain a crude artemisinin crystal 2 and a mother liquor 2; and S5. combining the crude artemisinin crystals 1 and 2, then dissolving same in an alcohol solvent and filtering same, heating the filtrate and then concentrating same to obtain a fine artemisinin product.

The present invention provides a new artemisinin-dipeptidyl vinyl based compound of Formula (I) or a pharmaceutically acceptable salt thereof and a process for the preparation thereof. The present invention further also provides a pharmaceutical composition comprising compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient to treat malaria. ##STR00001##

The present invention provides a new artemisinin-dipeptidyl vinyl based compound of Formula (I) or a pharmaceutically acceptable salt thereof and a process for the preparation thereof. The present invention further also provides a pharmaceutical composition comprising compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient to treat malaria. ##STR00001##

The present disclosure provides compositions comprising artemisinin-derived trimers and tetramers; methods of preparing these compositions; and methods for their use as medicaments.

The present disclosure provides compositions comprising artemisinin-derived trimers and tetramers; methods of preparing these compositions; and methods for their use as medicaments.