The present disclosure relates to an organic compound represented by Chemical Formula A or B, and an organic light-emitting diode comprising the same.

The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) where: (i) R.sup.1 is chosen from the group constituted of —CH(CH.sub.3).sub.2, —CH(CH.sub.3)CH.sub.2CH.sub.3, or cyclohexyl, (ii) X represents —CH.sub.2—CH.sub.2—, or —CH═CH—, (iii) R.sup.2 is chosen from

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or an OH group, (iv) R.sup.3 is OH or NOH, (v) represents a single bond when R.sup.3 is OH, or a double bond when R.sup.3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.

The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) where: (i) R.sup.1 is chosen from the group constituted of —CH(CH.sub.3).sub.2, —CH(CH.sub.3)CH.sub.2CH.sub.3, or cyclohexyl, (ii) X represents —CH.sub.2—CH.sub.2—, or —CH═CH—, (iii) R.sup.2 is chosen from

##STR00001##

or an OH group, (iv) R.sup.3 is OH or NOH, (v) represents a single bond when R.sup.3 is OH, or a double bond when R.sup.3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.

Provided are an organic compound, an electroluminescent material and an application thereof. The organic compound has a structure represented by Formula I. With the design of the spiro parent structure and the introduction of specific substituents, the organic compound can prevent materials from stacking and reduce the crystallinity of the molecule. The design of the spiro structure and substituents make the organic material have a high triplet state energy level Ti, and the nitrogen heterocycle and its linking groups make the organic compound have characteristics of good electron and hole transport performances. The organic compound has suitable HOMO and LUMO energy levels, facilitating the coordination of adjacent layers in terms of energy level. The organic compound also has advantages of high glass-transition temperature and good molecular thermal stability. Therefore, the organic compound can effectively improve the light emitting efficiency and lifetime of the device.

Provided are an organic compound, an electroluminescent material and an application thereof. The organic compound has a structure represented by Formula I. With the design of the spiro parent structure and the introduction of specific substituents, the organic compound can prevent materials from stacking and reduce the crystallinity of the molecule. The design of the spiro structure and substituents make the organic material have a high triplet state energy level Ti, and the nitrogen heterocycle and its linking groups make the organic compound have characteristics of good electron and hole transport performances. The organic compound has suitable HOMO and LUMO energy levels, facilitating the coordination of adjacent layers in terms of energy level. The organic compound also has advantages of high glass-transition temperature and good molecular thermal stability. Therefore, the organic compound can effectively improve the light emitting efficiency and lifetime of the device.

The invention is directed to the field of pro-fragrances used in detergents and cleaning agents, cosmetic agents and air fresheners, for example. The invention relates to particular cyclic ketals used as pro-fragrances. The invention also relates to detergents and cleaning agents, cosmetic agents and air fresheners containing ketals of the type. The invention further relates to a method for creating a long-lasting fragrance on surfaces and for repelling insects.

The invention is directed to the field of pro-fragrances used in detergents and cleaning agents, cosmetic agents and air fresheners, for example. The invention relates to particular cyclic ketals used as pro-fragrances. The invention also relates to detergents and cleaning agents, cosmetic agents and air fresheners containing ketals of the type. The invention further relates to a method for creating a long-lasting fragrance on surfaces and for repelling insects.

The present invention generally relates to artemisinin/dihydroartemisinin (DHA) derivatives, and their use for therapy, in particular cancer therapy. These tumor-homing artemisinin derivatives (THAD) comprise three moieties: an artemisinin/DHA or a derivative thereof, a heptamethine carbocyanine dye (HMCD) residue, and a linker that conjugates the HMCD dye residue to the artemisinin residue. The THAD include compounds wherein the linker is linked to one or two DHA residue(s) via one or more ether bonds, and wherein the linker is linked to two DHA residues via two bonds independently selected from ester, carbamate and thiocarbamate. The THAD of the invention provide improved growth inhibition of cancer cells. The present invention also relates to improved methods of cancer therapy wherein a THAD is administered to a cancer patient. In embodiments, one or more THAD may be co-administered in a coordinated administration schedule. Advantages of the THAD and their use include, among others, improved dose-response and/or efficacy. The invention also relates to new dyes, their drug conjugates, and processes of making them.

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.