The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

[Problem] Provided are a photoelectric conversion device and an imaging apparatus capable of improving quantum efficiency and a response speed. [Solving means] A first photoelectric conversion device according to one embodiment of the present disclosure includes a first electrode, a second electrode opposed to the first electrode, and a photoelectric conversion layer. The photoelectric conversion layer is provided between the first electrode and the second electrode and includes at least one type of one organic semiconductor material having crystallinity. Variation in a ratio between horizontally-oriented crystal and vertically-oriented crystal in the photoelectric conversion layer is three times or less between a case where film formation of the one organic semiconductor material is performed at a first temperature and a case where the film formation of the one organic semiconductor material is performed at a second temperature. The second temperature is higher than the first temperature.

A composition comprising an electron acceptor material and an electron donor material wherein the electron acceptor material is a compound of formula (I): EAG-EDG-EAG (I) wherein each EAG is an electron-accepting group and EDG is a group of formula (II): (II) wherein: n is at least 1; each m is independently 0 or at least 1; each X, Y and A is independently O, S or Se; Z, independently in each occurrence if n is greater than 1, is O, S, C═O or NR.sup.9 wherein R.sup.9 is H or a substituent; and R.sup.1-R.sup.8 are each independently selected from H or a substituent. The composition may be used as photosensitive organic layer of an organic photodetector.

##STR00001##

A composition comprising an electron acceptor material and an electron donor material wherein the electron acceptor material is a compound of formula (I): EAG-EDG-EAG (I) wherein each EAG is an electron-accepting group and EDG is a group of formula (II): (II) wherein: n is at least 1; each m is independently 0 or at least 1; each X, Y and A is independently O, S or Se; Z, independently in each occurrence if n is greater than 1, is O, S, C═O or NR.sup.9 wherein R.sup.9 is H or a substituent; and R.sup.1-R.sup.8 are each independently selected from H or a substituent. The composition may be used as photosensitive organic layer of an organic photodetector.

##STR00001##

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.

A heteroacene having the following formula (F) is described. An organic electroluminescence device comprises the heteroacene as a phosphorescent host, a fluorescent host, a hole blocking layer, or an electron transport layer. The heteroacene lowers a driving voltage, or increases a current efficiency or a half-life of the organic electroluminescence device. ##STR00001##

A heteroacene having the following formula (F) is described. An organic electroluminescence device comprises the heteroacene as a phosphorescent host, a fluorescent host, a hole blocking layer, or an electron transport layer. The heteroacene lowers a driving voltage, or increases a current efficiency or a half-life of the organic electroluminescence device. ##STR00001##