The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I).

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The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.

An organic electroluminescent element including a substrate, a pair of electrodes including an anode and a cathode, disposed on the substrate, and at least one organic layer including a light emitting layer, disposed between the electrodes, in which at least one layer of the organic layer(s) contains a compound represented by the following formula, has low driving voltage and excellent durability.

##STR00001##

(X.sup.1 to X.sup.11 represent CR.sup.0 or N, and R.sup.0 represents a hydrogen atom or a substituent. Adjacent two of X.sup.1 to X.sup.11 each independently represent at least CR.sup.0, R.sup.0s of the adjacent two CR.sup.0s are bonded to each other to form a ring, and only one R.sup.0 of the adjacent two CR.sup.0s represents an aryl group or a heteroaryl group.)

An organic electroluminescent element including a substrate, a pair of electrodes including an anode and a cathode, disposed on the substrate, and at least one organic layer including a light emitting layer, disposed between the electrodes, in which at least one layer of the organic layer(s) contains a compound represented by the following formula, has low driving voltage and excellent durability.

##STR00001##

(X.sup.1 to X.sup.11 represent CR.sup.0 or N, and R.sup.0 represents a hydrogen atom or a substituent. Adjacent two of X.sup.1 to X.sup.11 each independently represent at least CR.sup.0, R.sup.0s of the adjacent two CR.sup.0s are bonded to each other to form a ring, and only one R.sup.0 of the adjacent two CR.sup.0s represents an aryl group or a heteroaryl group.)

Degrader-antibody conjugates (DACs) are described, comprising anti-TM4SF1 antibodies, and antigen-binding fragments thereof. Degrader molecules as described comprise a ubiquitin E3 ligase binding group (E3LB) and a protein binding group (PB). Linkers may be utilized between the antibodies and the degrader molecules (L1) and between the ubiquitin E3 ligase binding group (E3LB) and the protein binding group (PB) of the degrader molecule (L2). Methods of use of said DACs are also described.

Degrader-antibody conjugates (DACs) are described, comprising anti-TM4SF1 antibodies, and antigen-binding fragments thereof. Degrader molecules as described comprise a ubiquitin E3 ligase binding group (E3LB) and a protein binding group (PB). Linkers may be utilized between the antibodies and the degrader molecules (L1) and between the ubiquitin E3 ligase binding group (E3LB) and the protein binding group (PB) of the degrader molecule (L2). Methods of use of said DACs are also described.

Provided are metalloorganic and organic compounds comprising a multicyclic system wherein a central nitrogen atom is part of two 5-membered rings which are fused together, and which are further fused together with three 6-membered aromatic rings. Also provided are formulations comprising these compounds. Further provided are organic light emitting devices (OLEDs) and related consumer products that utilize these compounds and compositions.

Provided are metalloorganic and organic compounds comprising a multicyclic system wherein a central nitrogen atom is part of two 5-membered rings which are fused together, and which are further fused together with three 6-membered aromatic rings. Also provided are formulations comprising these compounds. Further provided are organic light emitting devices (OLEDs) and related consumer products that utilize these compounds and compositions.

The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.