Patent classifications
C07D495/16
HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME
Provided is a heterocyclic compound of Chemical Formula 1:
##STR00001## a is a substituted or unsubstituted tetracyclic or higher aromatic or heteroaromatic ring, and b is a benzene or naphthalene ring; at least two of G1 to G3 are a group of Chemical Formula A, and any remaining group, and G101, is hydrogen, deuterium, halogen, cyano, nitro, or a substituted or unsubstituted: silyl, boron, alkyl, alkoxy, cycloalkyl, aryl, or heteroaryl group;
##STR00002## L1 and L2 are a direct bond, or a substituted or unsubstituted arylene or heteroarylene group; Ar1 and Ar2 are hydrogen, deuterium, halogen, cyano, nitro, or a substituted or unsubstituted: silyl, boron, alkyl, alkoxy, cycloalkyl, aryl, or a heteroaryl group, or a fused ring group of an aromatic hydrocarbon ring and aliphatic hydrocarbon ring, or bond to each other to form a substituted or unsubstituted heteroring; and an organic light emitting device including the same.
HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME
Provided is a heterocyclic compound of Chemical Formula 1:
##STR00001## a is a substituted or unsubstituted tetracyclic or higher aromatic or heteroaromatic ring, and b is a benzene or naphthalene ring; at least two of G1 to G3 are a group of Chemical Formula A, and any remaining group, and G101, is hydrogen, deuterium, halogen, cyano, nitro, or a substituted or unsubstituted: silyl, boron, alkyl, alkoxy, cycloalkyl, aryl, or heteroaryl group;
##STR00002## L1 and L2 are a direct bond, or a substituted or unsubstituted arylene or heteroarylene group; Ar1 and Ar2 are hydrogen, deuterium, halogen, cyano, nitro, or a substituted or unsubstituted: silyl, boron, alkyl, alkoxy, cycloalkyl, aryl, or a heteroaryl group, or a fused ring group of an aromatic hydrocarbon ring and aliphatic hydrocarbon ring, or bond to each other to form a substituted or unsubstituted heteroring; and an organic light emitting device including the same.
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
- Wilfried Braje ,
- George Doherty ,
- Katja Jantos ,
- Cheng Ji ,
- Andrew Judd ,
- Aaron Kunzer ,
- Anthony Mastracchio ,
- Xiaohong Song ,
- Andrew Souers ,
- Gerard Sullivan ,
- Zhi-Fu Tao ,
- Chunqiu Lai ,
- Jesse Teske ,
- Michael Wendt ,
- Patrick Brady ,
- Xilu Wang ,
- Thomas Penning ,
- Yujia Dai ,
- Jane Gong ,
- Roberto Risi ,
- Yiyun Yu ,
- Guidong ZHU
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
- Wilfried Braje ,
- George Doherty ,
- Katja Jantos ,
- Cheng Ji ,
- Andrew Judd ,
- Aaron Kunzer ,
- Anthony Mastracchio ,
- Xiaohong Song ,
- Andrew Souers ,
- Gerard Sullivan ,
- Zhi-Fu Tao ,
- Chunqiu Lai ,
- Jesse Teske ,
- Michael Wendt ,
- Patrick Brady ,
- Xilu Wang ,
- Thomas Penning ,
- Yujia Dai ,
- Jane Gong ,
- Roberto Risi ,
- Yiyun Yu ,
- Guidong ZHU
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER
The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER
The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
HETEROCYCLIC COMPOUND
One of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity. Another of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity and exhibits a protein degradation induction activity. The present invention provides a compound represented by formula (I) (the symbols in the formula are as defined in the present Description) and salts thereof.
##STR00001##
9 membered ring carbazole compounds
Novel 9 membered ring carbazole compounds are disclosed, which can be used as host materials etc. in an electroluminescent device. Compared with the existing host materials etc., these novel compounds can effectively modulate the charge transporting properties in the above materials and give OLEDs better performance. Also disclosed are an electroluminescent device and a formulation.