Patent classifications
C07D495/16
Inhibitors of Bruton's tyrosine kinase and method of their use
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I). ##STR00001##
Inhibitors of Bruton's tyrosine kinase and method of their use
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I). ##STR00001##
MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
METHODS OF SELECTIVE ARYL- AND HETEROARYL-NITROGEN BOND FORMATION
The disclosure is directed to methods of preparing compounds having the formula (I-A) and compounds involved in the preparation of such compounds.
##STR00001##
METHODS OF SELECTIVE ARYL- AND HETEROARYL-NITROGEN BOND FORMATION
The disclosure is directed to methods of preparing compounds having the formula (I-A) and compounds involved in the preparation of such compounds.
##STR00001##
NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS
The present invention describes nitrogen-containing heterocycles substituted by carbazole groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS
The present invention describes nitrogen-containing heterocycles substituted by carbazole groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
ORGANIC SEMICONDUCTOR ELEMENT, ORGANIC SEMICONDUCTOR COMPOSITION, METHOD OF MANUFACTURING ORGANIC SEMICONDUCTOR FILM, ORGANIC SEMICONDUCTOR FILM, AND COMPOUND AND POLYMER USING THE SAME
An organic semiconductor element in which an organic semiconductor layer contains a compound of Formula (1), a compound of Formula (2), and/or a compound of Formula (3) or contains a polymer having a structure of any one of formed by Formulae (8) to (10):
##STR00001##
in which X.sup.1 represents a nitrogen atom or CR.sup.a, and rings A to B each represent a specific nitrogen-containing ring; Y.sup.1 represents an oxygen atom, a sulfur atom, CR.sup.b.sub.2, or NR.sup.c; V.sup.1 represents NR.sup.d, an oxygen atom, a sulfur atom, or a selenium atom; R.sup.a to R.sup.d each represent a hydrogen atom or a substituent; R.sup.1 represents a specific substituent, and p is an integer of 0 to 2; n represents 1 or 2; and * represents a bonding site.
ORGANIC SEMICONDUCTOR ELEMENT, ORGANIC SEMICONDUCTOR COMPOSITION, METHOD OF MANUFACTURING ORGANIC SEMICONDUCTOR FILM, ORGANIC SEMICONDUCTOR FILM, AND COMPOUND AND POLYMER USING THE SAME
An organic semiconductor element in which an organic semiconductor layer contains a compound of Formula (1), a compound of Formula (2), and/or a compound of Formula (3) or contains a polymer having a structure of any one of formed by Formulae (8) to (10):
##STR00001##
in which X.sup.1 represents a nitrogen atom or CR.sup.a, and rings A to B each represent a specific nitrogen-containing ring; Y.sup.1 represents an oxygen atom, a sulfur atom, CR.sup.b.sub.2, or NR.sup.c; V.sup.1 represents NR.sup.d, an oxygen atom, a sulfur atom, or a selenium atom; R.sup.a to R.sup.d each represent a hydrogen atom or a substituent; R.sup.1 represents a specific substituent, and p is an integer of 0 to 2; n represents 1 or 2; and * represents a bonding site.
Macrocyclic MCL-1 Inhibitors and Methods of Use
- Patrick B. Brady ,
- Wilfried Braje ,
- Yujia Dai ,
- George A. Doherty ,
- Jane Gong ,
- Katja Jantos ,
- Cheng Ji ,
- Andrew S. Judd ,
- Aaron R. Kunzer ,
- Chunqiu Lai ,
- Anthony Mastracchio ,
- Roberto M. Risi ,
- Xiaohong Song ,
- Andrew J. Souers ,
- Gerard M. Sullivan ,
- Zhi-Fu Tao ,
- Jesse A. Teske ,
- Xilu Wang ,
- Michael D. Wendt ,
- Yiyun Yu ,
- Guidong ZHU ,
- Thomas D. Penning
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).