The present invention provides a compound having the structure:

##STR00001## wherein D, E and F are each independently NR.sub.1, CR.sub.2R.sub.3 or CR.sub.6R.sub.7, wherein one of D, E and F is NR.sub.1 and the remaining two are CR.sub.2R.sub.3 or CR.sub.6R.sub.7, wherein R.sub.1 is H or -(alkyl), and wherein R.sub.2, R.sub.3, R.sub.6 and R.sub.7 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl or -alkylaryl; X.sub.1 is C or N; X.sub.2 is O, S, N, NR.sub.14 or CR.sub.15, wherein R.sub.14 is H, -(alkyl) or -cycloalkyl, wherein R.sub.15 is H, -(alkyl) or -cycloalkyl, and wherein X.sub.2 is other than N when X.sub.1 is N; α and β represent a bond that is present or absent, and wherein either α or β is present, wherein when α is present, then X.sub.1 is C and X.sub.2 is O, S or NR.sub.14, or when β is present, then X.sub.1 is N and X.sub.2 is N or CR.sub.15; R.sub.4, R.sub.5, R.sub.8 and R.sub.9 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl, -alkylaryl, —OH, —O(alkyl), —OAc, —S(alkyl), —NH.sub.2, —NH(alkyl), —N(alkyl).sub.2, —COOH, —CO.sub.2(alkyl), —CONH.sub.2, —CONH(alkyl), —CON(alkyl).sub.2 or —CN, wherein when D is NR.sub.1 then R.sub.4 and R.sub.5 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl or -alkylaryl, wherein when F is NR.sub.1 then R.sub.8 and R.sub.9 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl or -alkylaryl or R.sub.1 and R.sub.4 together form a —(CH.sub.2).sub.m—, wherein m represents an integer from 2 to 4; and R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are each independently H, halogen, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -(aryl), -(heteroaryl), —OH, —OAc, —O(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —SH, —S(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —NH.sub.2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl), —NH-(aryl), —NH-(heteroaryl), —CO.sub.2(alkyl), —CONH.sub.2, —CN, —CF.sub.3, —CF.sub.2H, —OCF.sub.3 or NO.sub.2 or R.sub.10 and R.sub.11 together form a —O(CH.sub.2)O— or R.sub.11 and R.sub.12 together form a —O(CH.sub.2)O— or R.sub.12 and R.sub.13 together form a —O(CH.sub.2)O—; wherein when X.sub.1 is C, X.sub.2 is NR.sub.14, and D is CR.sub.2R.sub.3, E is NR.sub.1, F is CR.sub.6R.sub.7, then (i) R.sub.14 and at least two of R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are other than hydrogen, or (ii) one of R.sub.2, R.sub.3, R.sub.6 and R.sub.7 i

The present disclosure provides for compounds of Formula (I)

##STR00001##

wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

The present disclosure provides for compounds of Formula (I)

##STR00001##

wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Epoxide functionalized polyaromatic feedstocks and processes for their preparation are described. The processes involve functionalizing polyaromatic hydrocarbon molecules and/or polyheterocyclic molecules present in petroleum or petrochemical streams with epoxide. The epoxide functionalized poly aromatic feedstock can be further treated so as to effect oligomerization or polymerization. The oligomers or polymers may be thermoplastic or thermoset materials and may find use in, for example, infrastructure applications, composites, fillers, fire retardants and 3-D printing materials.

Epoxide functionalized polyaromatic feedstocks and processes for their preparation are described. The processes involve functionalizing polyaromatic hydrocarbon molecules and/or polyheterocyclic molecules present in petroleum or petrochemical streams with epoxide. The epoxide functionalized poly aromatic feedstock can be further treated so as to effect oligomerization or polymerization. The oligomers or polymers may be thermoplastic or thermoset materials and may find use in, for example, infrastructure applications, composites, fillers, fire retardants and 3-D printing materials.

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

The present disclosure provides for compounds of Formula (I)

##STR00001##

wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).