The present specification provides a compound having a spiro structure and an organic light emitting device including the same.

The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

Provided are an organic compound, an electroluminescent material and an application thereof. The organic compound has a structure represented by Formula I. With the design of the spiro parent structure and the introduction of specific substituents, the organic compound can prevent materials from stacking and reduce the crystallinity of the molecule. The design of the spiro structure and substituents make the organic material have a high triplet state energy level Ti, and the nitrogen heterocycle and its linking groups make the organic compound have characteristics of good electron and hole transport performances. The organic compound has suitable HOMO and LUMO energy levels, facilitating the coordination of adjacent layers in terms of energy level. The organic compound also has advantages of high glass-transition temperature and good molecular thermal stability. Therefore, the organic compound can effectively improve the light emitting efficiency and lifetime of the device.

Provided are an organic compound, an electroluminescent material and an application thereof. The organic compound has a structure represented by Formula I. With the design of the spiro parent structure and the introduction of specific substituents, the organic compound can prevent materials from stacking and reduce the crystallinity of the molecule. The design of the spiro structure and substituents make the organic material have a high triplet state energy level Ti, and the nitrogen heterocycle and its linking groups make the organic compound have characteristics of good electron and hole transport performances. The organic compound has suitable HOMO and LUMO energy levels, facilitating the coordination of adjacent layers in terms of energy level. The organic compound also has advantages of high glass-transition temperature and good molecular thermal stability. Therefore, the organic compound can effectively improve the light emitting efficiency and lifetime of the device.

A heteroaromatic compound which can be used as the fluorescent guest material in the light emitting layer of the organic electroluminescence device is disclosed. The organic electroluminescence device employing the heteroaromatic compound of the present invention shows lower power consumption, higher efficiency, and longer half-life time than the existed organic electroluminescence devices.

A heteroaromatic compound which can be used as the fluorescent guest material in the light emitting layer of the organic electroluminescence device is disclosed. The organic electroluminescence device employing the heteroaromatic compound of the present invention shows lower power consumption, higher efficiency, and longer half-life time than the existed organic electroluminescence devices.

The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound is a bipolar compound having a p-type moiety and an n-type moiety and has high energy level and proper energy bandgap for an emissive layer of the OLED. As the organic compound is applied into the emissive layer, the OLED can maximize its luminous properties as holes and electrons are recombined uniformly over the whole area in an emitting material layer (EML).

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The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound is a bipolar compound having a p-type moiety and an n-type moiety and has high energy level and proper energy bandgap for an emissive layer of the OLED. As the organic compound is applied into the emissive layer, the OLED can maximize its luminous properties as holes and electrons are recombined uniformly over the whole area in an emitting material layer (EML).

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Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.