Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

The invention relates to an organic polyspiralgrid nanopolymer material and a preparation method thereof, and belongs to the field of nanotechnology and organic electronics. The structure of the organic polyspiralgrid nanopolymer material is composed of grids containing a spiro ring that serves as a repeat unit to form a special nano polymer, and the structure shares the spiro ring structure. A synthetic method thereof relates to a synthon containing the spiro ring, and by means of a Friedel-Crafts reaction, an organic spirogrid and a nano polymer thereof are built. By means of reasonable molecular design and the Friedel-Crafts reaction with the advantages of being mild in reaction condition, high in yield, high in selectivity, simple in posttreatment, green, free of toxicity and the like, the problems that a traditional polymer molecule is complex in synthesis step, toxic in posttreatment, large in pollution and the like are solved.

The invention relates to an organic polyspiralgrid nanopolymer material and a preparation method thereof, and belongs to the field of nanotechnology and organic electronics. The structure of the organic polyspiralgrid nanopolymer material is composed of grids containing a spiro ring that serves as a repeat unit to form a special nano polymer, and the structure shares the spiro ring structure. A synthetic method thereof relates to a synthon containing the spiro ring, and by means of a Friedel-Crafts reaction, an organic spirogrid and a nano polymer thereof are built. By means of reasonable molecular design and the Friedel-Crafts reaction with the advantages of being mild in reaction condition, high in yield, high in selectivity, simple in posttreatment, green, free of toxicity and the like, the problems that a traditional polymer molecule is complex in synthesis step, toxic in posttreatment, large in pollution and the like are solved.

The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD). ##STR00001##

The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD). ##STR00001##

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.