The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.

The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and, in particular, as glycosidase inhibitors.

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

This disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof: in which m, p, A, Ar.sup.1, Ar.sup.2, Ar.sup.3, R.sup.1, R.sup.2, and R.sup.3 are defined in the specification. The compounds of formula (I) can be used as CGRP antagonists and can be used to treat

##STR00001##

The invention provides compounds of formula (I): and salts thereof wherein ring A, R.sup.2, HET, X, n, and R.sup.3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

##STR00001##

The invention provides compounds of formula (I): and salts thereof wherein ring A, R.sup.2, HET, X, n, and R.sup.3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

##STR00001##

An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like.

Provided are a condensed heterocyclic compound represented by the general formula (1):

##STR00001##

{wherein R.sup.1 represents an ethyl group, R.sup.2 represents a cycloalkyl group, R.sup.3 represents a haloalkyl group, A, A.sup.2 and A.sup.3 each represent a nitrogen atom or a CH group, A.sup.1 represents N-Me, m represents 0 or 2, and n represents 1} or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.

An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like.

Provided are a condensed heterocyclic compound represented by the general formula (1):

##STR00001##

{wherein R.sup.1 represents an ethyl group, R.sup.2 represents a cycloalkyl group, R.sup.3 represents a haloalkyl group, A, A.sup.2 and A.sup.3 each represent a nitrogen atom or a CH group, A.sup.1 represents N-Me, m represents 0 or 2, and n represents 1} or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.

Substituted pyrimidinium compounds of the general formula (I) and their uses for combating animal pests

The present invention relates to substituted pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these substituted pyrimidinium compounds and of compositions thereof, for combating and controlling animal pests. Furthermore the invention relates also to pesticidal methods of applying such substituted pyrimidinium compounds.

The substituted pyrimidinium compounds of the present invention are defined by the following general formula (I):

##STR00001##

wherein X, Y, Z, R.sup.1, R.sup.2, A and Het are defined as in the description.