The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

##STR00001##

An isolated compound of Formula I and salts thereof are provided: ##STR00001##
wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C.sub.43H.sub.69ClN.sub.4O.sub.10S.sub.2 or C.sub.43H.sub.69BrN.sub.4O.sub.10S.sub.2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.

An isolated compound of Formula I and salts thereof are provided: ##STR00001##
wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C.sub.43H.sub.69ClN.sub.4O.sub.10S.sub.2 or C.sub.43H.sub.69BrN.sub.4O.sub.10S.sub.2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

##STR00001##

Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

##STR00001##

The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

##STR00001##