The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

The invention provides compounds of Formula (I)

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as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators. ##STR00001##

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators. ##STR00001##