Benzyl derivative compounds having peroxisome proliferator-activated receptor α (PPARα) agonistic activity, kits and compositions containing such compounds, and methods of their use in enhancing PPARα activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema.

Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof.

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Provided are molecular probes for hyperpolarized .sup.15N magnetic resonance spectroscopic imaging (MRSI) and their use for detecting reactive species (e.g., hydrogen peroxide) and imaging of oxidative stress. In particular, .sup.15N-boronobenzyl-4-cyanopyridinium (.sup.15N-BBCP) demonstrated highly favorable physicochemical and hyperpolarization properties, including long spin-lattice relaxation time (T.sub.1) and distinguishable .sup.15N chemical shift signals, that make it an effective reaction-based sensing probe for non-invasive, real-time detection of H.sub.2O.sub.2.

Process for the industrial synthesis of the compound of formula (I): ##STR00001##

The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

The present disclosure provides certain bicyclic heteroaryl compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. In some embodiments, the bicyclic heteroaryl compounds includes those of Formula (I). Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

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A light emitting device of an embodiment includes a first electrode, a second electrode disposed on the first electrode, and an emission layer disposed between the first electrode and the second electrode. The emission layer may include a polycyclic compound of an embodiment represented by Formula 1. The light emitting device including the polycyclic compound of an embodiment may show improved efficiency and device life.

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The present application relates to methods for treatment of bacteria and viruses with C.sub.2-C.sub.7 alkyl boronic acids to reduce growth and virulence.

The invention relates to compounds comprising functional substituents in a specific spatial arrangement, devices containing same, and the preparation and use thereof.