The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

The present disclosure provides electrolytes for an electrochemical device. In some embodiments, these electrolytes are Mg salts comprising 10-vertex or 12-vertex carborane anions. The present disclosure also provides processes for preparing electrolytes for an electrochemical device. In some embodiments, the process comprises reduction of a reactive cation complexed with a 10-vertex or 12-vertex carborane or 12-vertex borate anion to form metal carborane or borate electrolytes. In some embodiments, the process comprises comproportionating a Mg.sup.+2 10-vertex or 12-vertex carborane salt to form a Mg.sup.+1 electrolyte comprising a 10-vertex or 12-vertex carborane. The present disclosure further provides electrochemical devices comprising the electrolytes disclosed herein. In some embodiments, the electrochemical device comprises an electrolyte that is stable at an electrical potential greater than 4 V vs Mg.sup.0/+2. Also provided herein are heterocyctes bearing the 10, 11, and 12 vertex carborane anions for application as catalyst and battery electrolyte components. The methods of making are also disclosed.

The present disclosure provides electrolytes for an electrochemical device. In some embodiments, these electrolytes are Mg salts comprising 10-vertex or 12-vertex carborane anions. The present disclosure also provides processes for preparing electrolytes for an electrochemical device. In some embodiments, the process comprises reduction of a reactive cation complexed with a 10-vertex or 12-vertex carborane or 12-vertex borate anion to form metal carborane or borate electrolytes. In some embodiments, the process comprises comproportionating a Mg.sup.+2 10-vertex or 12-vertex carborane salt to form a Mg.sup.+1 electrolyte comprising a 10-vertex or 12-vertex carborane. The present disclosure further provides electrochemical devices comprising the electrolytes disclosed herein. In some embodiments, the electrochemical device comprises an electrolyte that is stable at an electrical potential greater than 4 V vs Mg.sup.0/+2. Also provided herein are heterocyctes bearing the 10, 11, and 12 vertex carborane anions for application as catalyst and battery electrolyte components. The methods of making are also disclosed.

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

Compounds based on an element from Groupe IIIA (column 13) of the periodic table of the elements, such as boron, aluminum, gallium or indium, are here described, as well as their processes of preparation and their use as salts and/or additives, for instance, in combination with other salts in electrolyte compositions for electrochemical cells, inter alia, in electrolyte compositions in the presence of a liquid solvent and/or a solvating polymer, the electrolyte being in liquid, gel or solid form.

Compounds based on an element from Groupe IIIA (column 13) of the periodic table of the elements, such as boron, aluminum, gallium or indium, are here described, as well as their processes of preparation and their use as salts and/or additives, for instance, in combination with other salts in electrolyte compositions for electrochemical cells, inter alia, in electrolyte compositions in the presence of a liquid solvent and/or a solvating polymer, the electrolyte being in liquid, gel or solid form.