The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, -lactamase inhibitors (BLIs).

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, -lactamase inhibitors (BLIs).

Provided are a material for an organic EL device that improves the luminous efficacy of a device, sufficiently secures its driving stability, and has a simple construction, and an organic EL device using the material. The material for an organic EL device is formed of a carborane compound having a structure in which a dibenzofuranyl group is bonded to a carborane ring. In addition, the material for an organic EL device is preferably used in a light-emitting layer, an electron-transporting layer, or a hole-blocking layer of an organic electroluminescent device having the light-emitting layer between an anode and a cathode laminated on a substrate. Also disclosed is an organic electroluminescent device using the material for an organic EL device as a host material for a light-emitting layer containing a phosphorescent light-emitting dopant and the host material.

Provided are a material for an organic EL device that improves the luminous efficacy of a device, sufficiently secures its driving stability, and has a simple construction, and an organic EL device using the material. The material for an organic EL device is formed of a carborane compound having a structure in which a dibenzofuranyl group is bonded to a carborane ring. In addition, the material for an organic EL device is preferably used in a light-emitting layer, an electron-transporting layer, or a hole-blocking layer of an organic electroluminescent device having the light-emitting layer between an anode and a cathode laminated on a substrate. Also disclosed is an organic electroluminescent device using the material for an organic EL device as a host material for a light-emitting layer containing a phosphorescent light-emitting dopant and the host material.

Boron Enriched Linker (BEL) compositions and methods of making BELs are disclosed herein. Consequently, the BELs can be conjugated to antibodies or antibody fragments to create Antibody Boron Conjugates (ABCs) to provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

Boron Enriched Linker (BEL) compositions and methods of making BELs are disclosed herein. Consequently, the BELs can be conjugated to antibodies or antibody fragments to create Antibody Boron Conjugates (ABCs) to provide a method of treating cancer, immunological disorders and other disease by utilizing a Neutron Capture Therapy modality.

The present document describes compounds resulting from the complexation of quaternary ammonium compounds with boric acid and/or its derivatives, and methods of making the same, and methods of using the same for the treatment of pathogenic infections.

The present document describes compounds resulting from the complexation of quaternary ammonium compounds with boric acid and/or its derivatives, and methods of making the same, and methods of using the same for the treatment of pathogenic infections.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, -lactamase inhibitors (BLIs).